Patient attrition in a comparative outcome study of depression. A follow-up report.
Patient attrition in a comparative outcome study of depression. A follow-up report.
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抑郁症比较结果研究中的患者流失。
DOI：
10.1016/0165-0327(84)90021-1
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发表时间：
1984
影响因子：
6.6
通讯作者：
Murphy,GE
中科院分区：
文献类型：
--
作者：
Simons,AD;Levine,JL;Lustman,PJ;Murphy,GE
87名中重度抑郁症精神科门诊患者被随机分配到12周的认知治疗组（n = 24）、药物治疗组（n =24）、认知治疗加药物治疗组（n = 22）或认知治疗加活性安慰剂组（n = 17）。70名患者完成了治疗方案; 17名患者在治疗期结束前退出。完成者和辍学者在预处理时在人口统计学变量、抑郁症、认知功能或社会适应方面没有差异。对17名脱落患者中的16名进行了随访和访谈，以评估其临床状态和停止治疗的原因。两组在随访时都没有抑郁。与接受的治疗类型有关的实际问题似乎是患者决定退出的最大原因。分配到联合治疗的患者比分配到单一治疗方式的患者更有可能完成研究方案。这些研究结果进行了讨论，其临床实践和成果研究的影响。
Eighty-seven moderately to severely depressed psychiatric outpatients were randomly assigned to 12 weeks of cognitive therapy (n = 24), pharmacotherapy (n =24), cognitive therapy plus pharmacotherapy (n = 22) or cognitive therapy plus active placebo (n = 17). Seventy patients completed the treatment protocol; 17 dropped out before the end of the treatment period. Completers and dropouts did not differ at pretreatment on demographic variables, measures of depression, cognitive functioning or social adjustment. Sixteen of the 17 patients who dropped out were followed up and interviewed to assess their clinical status and reasons for discontinuing treatment. Neither group remained depressed at follow-up. Practical matters and issues related to the type of treatment received seemed to contribute most to patient's decision to drop out. Patients assigned to the combination therapies were more likely to complete the research protocol than those assigned to single treatment modalities. These findings are discussed in terms of their implications for clinical practice and outcome research.
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影响因子：
6.7
作者：
S. Weschenfelder;M.J.C. Fonseca;B. Costa;C. P. Borges
通讯作者：
C. P. Borges
通过使用三个连锁 DNA 标记改进了亨廷顿病的预测测试。
影响因子：
9.8
作者：
M. Hayden;C. Robbins;D. Allard;J. Haines;S. Fox;J. Wasmuth;M. Fahy;M. Bloch
通讯作者：
M. Bloch
影响因子：
4
作者：
Lindsay A. Farrer;Richard H. Myers;Adrienne Cupples;A. P. M. Conneally
通讯作者：
Lindsay A. Farrer;Richard H. Myers;Adrienne Cupples;A. P. M. Conneally
使用连锁 DNA 标记对亨廷顿病进行预测测试。
DOI：
10.1056/nejm198803033180903
发表时间：
1988
期刊：
The New England journal of medicine
影响因子：
--
作者：
Meissen,GJ;Myers,RH;Mastromauro,CA;Koroshetz,WJ;Klinger,KW;Farrer,LA;Watkins,PA;Gusella,JF;Bird,ED;Martin,JB
通讯作者：
Martin,JB
影响因子：
9.8
作者：
Conneally Pm
通讯作者：
Conneally Pm