Robotic Delivery of Complex Radiation Volumes for Small Animal Research.
Robotic Delivery of Complex Radiation Volumes for Small Animal Research.
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用于小动物研究的复杂辐射量的机器人传输。
DOI：
10.1109/robot.2010.5509898
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Kazanzides,Peter
中科院分区：
文献类型：
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作者：
Matinfar,Mohammad;Iordachita,Iulian;Wong,John;Kazanzides,Peter
小动物辐射研究平台（SARRP）是一种新型的完整系统，能够在机器人控制下使用锥形束CT（CBCT）图像引导向小动物中的目标提供多方向（焦点），千伏辐射场。SARRP向多个动物模型提供高度聚焦光束的能力提供了新的研究机会，可以更真实地连接实验室研究和临床翻译。本文介绍了设计和操作的SARRP精确的辐射输送。不同的交付程序，使系统能够通过一系列的点，代表一个复杂的形状辐射。一个特别有趣的情况是壳剂量辐照，其目标是向形状表面提供高剂量的辐射，而向形状内部提供最小剂量。递送剂量壳的能力允许对肿瘤如何与其微环境相互作用以维持其生长并导致其抗性或复发的机制研究。
The Small Animal Radiation Research Platform (SARRP) is a novel and complete system capable of delivering multidirectional (focal), kilo-voltage radiation fields to targets in small animals under robotic control using cone-beam CT (CBCT) image guidance. The capability of the SARRP to deliver highly focused beams to multiple animal models provides new research opportunities that more realistically bridge laboratory research and clinical translation. This paper describes the design and operation of the SARRP for precise radiation delivery. Different delivery procedures are presented which enable the system to radiate through a series of points, representative of a complex shape. A particularly interesting case is shell dose irradiation, where the goal is to deliver a high dose of radiation to the shape surface, with minimal dose to the shape interior. The ability to deliver a dose shell allows mechanistic research of how a tumor interacts with its microenvironment to sustain its growth and lead to its resistance or recurrence.