Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma.
Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma.
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DOI：
10.3892/ol.2011.428
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发表时间：
2012
期刊：
影响因子：
2.9
通讯作者：
Yi Wang;J. Ikeda;Nur Rahadiani;S. Mamat;Y. Ueda;T. Tian;T. Enomoto;T. Kimura;K. Aozasa;E. Morii
中科院分区：
文献类型：
--
作者：
Yi Wang;J. Ikeda;Nur Rahadiani;S. Mamat;Y. Ueda;T. Tian;T. Enomoto;T. Kimura;K. Aozasa;E. Morii
Elongator Protein 3(ELP3)是RNA聚合酶II延伸器复合体的催化亚基，参与多种功能，包括转录延长、染色质修饰和细胞骨架调节。本研究采用免疫组织化学方法检测ELP3在正常子宫组织和子宫内膜样腺癌组织中的表达。ELP3在子宫内膜周期的增殖期和分泌期均有大量表达。然而，ELP3的表达水平在不同的子宫内膜样腺癌中有所不同。在子宫内膜样腺癌中，ELP3低表达与高T因子(p=0.036)、肿瘤分期(p=0.001)、淋巴结转移(p<；0.001)、化疗耐药(p=0.045)、复发(p=0.004)和预后不良(p=0.003)有关。单因素和多因素分析显示ELP3低表达是预后不良的独立因素。总之，这是第一个研究ELP3在癌症中表达的临床意义的研究。
Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal uterus tissue and uterine endometrioid adenocarcinoma tissue. ELP3 was abundantly expressed in both the proliferative and secretory phases of the endometrial cycle. However, ELP3 expression levels varied among cases of endometrioid adenocarcinoma. In patients with endometrioid adenocarcinoma, a low ELP3 expression was correlated to a high T-factor (p=0.036), tumor stage (p=0.001), lymph node metastasis (p<0.001), resistance to chemotherapy (p=0.045), recurrence (p=0.004) and poor prognosis (p=0.003). Univariate and multivariate analyses revealed that a low ELP3 expression was an independent factor for poor prognosis. In conclusion, this is the first study to examine the clinical implications of ELP3 expression in cancer.