Nanocomposite of Au and black phosphorus quantum dots as versatile probes for amphibious SERS spectroscopy, 3D photoacoustic imaging and cancer therapy
Nanocomposite of Au and black phosphorus quantum dots as versatile probes for amphibious SERS spectroscopy, 3D photoacoustic imaging and cancer therapy
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Au 和黑磷量子点纳米复合材料作为两栖 SERS 光谱、3D 光声成像和癌症治疗的多功能探针
DOI：
10.1016/j.giant.2021.100073
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发表时间：
2021-07-31
期刊：
影响因子：
7
通讯作者：
Wu, Jun
中科院分区：
文献类型：
--
作者：
Chen, Haolin;Liu, Zhiming;Wu, Jun
为了拓展Au和黑磷的生物成像应用，本研究制备了用于多种治疗诊断应用的黑磷量子点Au杂化物（Au-BPQD纳米杂化物）。通过简单改变BPQDs和Au ~（3+）的比例，BPQDs辅助Au ~（3+）还原得到了两种不同功能的纳米杂化物。较少的BPQD导致具有核-壳结构的小尺寸Au-BPQD纳米杂化物（S-ABP）。S-ABPs具有上级的近红外（NIR）表面增强拉曼散射（Sers）活性，可用于生物分子的指纹分析。由于在生物拉曼静默区域中约2190 cm（-1）处的独特拉曼带，这对于无干扰生物成像也是非常有希望的，这是Au或BP基纳米材料无法实现的。同时，BPQD的进一步加入将导致大尺寸的Au-BPQD纳米杂化物（L-ABPs）具有强的近红外光吸收，这有利于体内三维光声成像以及肿瘤的光热治疗。这项工作报告了多功能的纳米治疗诊断平台，用于两栖Sers光谱，3D光声成像和癌症治疗，这为BP和Au基纳米材料的生物医学应用打开了一扇新的大门。
To expand the bioimaging applications of Au and black phosphorus, black phosphorus quantum dot Au hybrids (Au-BPQD nanohybrids) are fabricated for multiple theranostic applications in this study. By simply varying the ratios of BPQDs and Au3+, the BPQDs assisted Au3+ reduction outputs two kinds of nanohybrids with different functions. The less BPQDs lead to small size Au-BPQD nanohybrids (S-ABPs) with a core-shell structure. S-ABPs exhibit superior near-infrared (NIR) surface-enhanced Raman scattering (SERS) activity for the fingerprint analysis of biomolecules. It's also very promising for interference-free bioimaging due to the distinctive Raman band at around 2190 cm(-1) in the biologically Raman-silent region, which cannot be achieved by Au or BP-based nanomaterials. Meanwhile, further addition of BPQDs would lead to large size Au-BPQD nanohybrids (L-ABPs) with strong NIR optical absorption, which facilitates the in vivo 3D photoacoustic imaging as well as the photothermal therapy against tumor. This work reports versatile nanotheranostic platforms for amphibious SERS spectroscopy, 3D photoacoustic imaging and cancer therapy, which opens a new door for the biomedical applications of BP and Au based nanomaterials.