Effect of saiko-ka-ryukotsu-borei-to on the stress-induced increase of serum corticosterone in mice.
Effect of saiko-ka-ryukotsu-borei-to on the stress-induced increase of serum corticosterone in mice.
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Saiko-ka-ryukotsu-borei-to 对应激引起的小鼠血清皮质酮升高的影响。
DOI：
10.1248/bpb.18.563
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发表时间：
1995
影响因子：
2
通讯作者：
T. Ando
中科院分区：
文献类型：
--
作者：
K. Sasaki;K. Suzuki;F. Yoshizaki;T. Ando
采用小鼠不同应激模型，观察柴胡对应激所致小鼠血清皮质酮升高的影响。束缚应激、强迫游泳应激、电击应激、心理应激和条件性恐惧应激均显著升高血清皮质酮水平。SRBT(10、60、100、600、1000 mg/kg，P.O.)预先给药，后两种模型的血药浓度均呈剂量依赖性降低。因此，这一行动似乎在涉及情感因素的压力中有效，但在身体压力模型中无效。这些结果表明，与生理变化相比，SRBT的抗应激作用强烈依赖于心理变化的程度。
The effect of Saiko-ka-ryukotsu-borei-to (SRBT) on the stress-induced enhancement of serum corticosterone in various stress models was investigated in mice. The serum corticosterone was elevated significantly by immobilized stress, forced-swim stress, electric-shock stress, psychological stress and conditioned-fear stress, respectively. The concentration in the last two models was decreased in a dose-dependent manner by pre-administration of SRBT (10, 60, 100, 600 and 1000 mg/kg, p.o.). Therefore, this action seems to be effective in stress involving emotional factors but ineffective in physical stress models. These results indicate that the anti-stress effect of SRBT is dependent strongly on the degree of psychological change compared with physical change in mice.