Biomolecular structure and dynamics - Experiment and theory
Biomolecular structure and dynamics - Experiment and theory
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DOI：
10.1016/0731-7085(95)01640-6
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发表时间：
1996-01-01
影响因子：
3.4
通讯作者：
Kordel, J
中科院分区：
文献类型：
--
作者：
Forsen, S;Kordel, J
生物大分子是复杂的系统，为了了解它们的内部运作，我们需要来自许多来源的信息。在这篇综述中，我们提出了一些基本原则，目前的方法选择的结构和动力学研究的生物大分子。这些学科之间的相互作用-X射线衍射，核磁共振光谱和理论计算-已经非常富有成效，我们在这一领域的生物科学的知识正在迅速增加，由于这种交叉施肥。虽然蛋白质的结构方面越来越好地研究和理解，但我们仍然需要更多地强调其动力学性质。
Biological macromolecules are complex systems and in order to understand their inner workings we need information from many sources. In this review we present some of the underlying principles for current methods of choice for structural and dynamical studies of biological macromolecules. Interplay between these disciplines-X-ray diffraction,;nuclear magnetic resonance spectroscopy and theoretical calculations-has been extremely fruitful and our knowledge in this area of bioscience is rapidly increasing due to this cross-fertilization. While structural aspects of proteins; are increasingly well studied and understood we do however still need to put more emphasis on their dynamical properties.