Exercise-associated increases in cardiac biomarkers
Exercise-associated increases in cardiac biomarkers
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DOI：
10.1249/mss.0b013e318172cf22
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发表时间：
2008-08-01
期刊：
影响因子：
--
通讯作者：
Kindermann, Wilfried
中科院分区：
文献类型：
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作者：
Scharhag, Juergen;George, Keith;Kindermann, Wilfried
目前，耐力运动引起心肌损伤的风险仍存在争议，因为有报道称，运动相关的心脏生物标志物肌钙蛋白和B型利钠肽（BNP）增加;这些标志物通常分别在急性心肌梗死和慢性心力衰竭患者中升高。心脏生物标志物的运动相关升高可存在于精英运动员和休闲运动员中，特别是在长时间和剧烈的耐力运动后（例如，马拉松和超级铁人三项）。然而，与心脏病患者相比，目前尚不清楚明显健康的运动员中运动相关的外观或心脏生物标志物的增加是否代表临床上显著的心脏损伤或确实是耐力运动的生理反应的一部分。此外，运动员运动后心脏生物标志物升高可能会给临床医生的鉴别诊断带来困难，并可能导致不适当的后果。因此，本文旨在为运动员、教练、科学家和临床医生提供运动相关的心脏生物标志物肌钙蛋白T和1、缺血修饰白蛋白（BNP）及其裂解的无活性片段N-末端BNP原的变化概述。
At present, the risk of myocardial damage by endurance exercise is under debate because of reports on exercise-associated increases in cardiac biomarkers troponin and B-type natriuretic peptide (BNP); these markers are typically elevated in patients with acute myocardial infarction and chronic heart failure, respectively. Exercise-associated elevations of cardiac biomarkers can be present in elite and in recreational athletes, especially after prolonged and strenuous endurance exercise bouts (e.g., marathon and ultratriathlon). However, in contrast to cardiac patients, it is still unclear if the exercise-associated appearance or increase in cardiac biomarkers in obviously healthy athletes represents clinically significant cardiac insult or is indeed part of the physiological response to endurance exercise. In addition, elevations in cardiac biomarkers in athletes after exercise may generate difficulties for clinicians in terms of differential diagnosis and may result in inappropriate consequences. Therefore, the aim of this article is to provide an overview of exercise-associated alterations of the cardiac biomarkers troponin T and 1, ischemia-modified albumin, BNP, and its cleaved inactive fragment N-terminal pro BNP for the athlete, coach, scientist, and clinician.