Neural Circuits Underlying Fly Larval Locomotion.
Neural Circuits Underlying Fly Larval Locomotion.
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DOI：
10.2174/1381612822666161208120835
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发表时间：
2017
影响因子：
3.1
通讯作者：
Nose A
中科院分区：
文献类型：
--
作者：
Kohsaka H;Guertin PA;Nose A
运动是一种复杂的运动行为，可以根据物种和病理或环境条件使用各种策略以不同的方式表达。四足或两足行走、跑步、游泳、飞行和滑翔构成了一些运动模式，使身体在所有情况下都能从一个地方移动到另一个地方。尽管在运动模式上存在这些明显差异，但脊椎动物和无脊椎动物物种至少部分地共享可比较的运动节律和模式生成和调制的神经控制机制。近年来，这些控制系统的遗传方面的研究取得了重大进展。特别是使用果蝇模型和制剂所做的发现有助于进一步了解基因在运动中的关键作用。这篇综述着重于一些主要的研究结果，在幼虫果蝇，同时简要总结了使用这种强大的动物模型研究神经运动系统的基本优势。
Locomotion is a complex motor behavior that may be expressed in different ways using a variety of strategies depending upon species and pathological or environmental conditions. Quadrupedal or bipedal walking, running, swimming, flying and gliding constitute some of the locomotor modes enabling the body, in all cases, to move from one place to another. Despite these apparent differences in modes of locomotion, both vertebrate and invertebrate species share, at least in part, comparable neural control mechanisms for locomotor rhythm and pattern generation and modulation. Significant advances have been made in recent years in studies of the genetic aspects of these control systems. Findings made specifically using Drosophila (fruit fly) models and preparations have contributed to further understanding of the key role of genes in locomotion. This review focuses on some of the main findings made in larval fruit flies while briefly summarizing the basic advantages of using this powerful animal model for studying the neural locomotor system.