The neuronal sources of EEG: Modeling of simultaneous scalp and intracerebral recordings in epilepsy
The neuronal sources of EEG: Modeling of simultaneous scalp and intracerebral recordings in epilepsy
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DOI：
10.1016/j.neuroimage.2008.04.185
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发表时间：
2008-08-01
期刊：
影响因子：
5.7
通讯作者：
Wendling, F.
中科院分区：
文献类型：
--
作者：
Cosandier-Rimele, D.;Merlet, I.;Wendling, F.
在许多利用脑电图研究脑功能的应用中，一个中心问题往往是将记录的信号与潜在的神经元活动来源的时空组织联系起来。一个模型尝试定量调查这种不完全已知的关系被报道。所提出的可信的脑电图生成模型依赖于神经元活动源的准确表示。它结合了对源的空间特征的解剖学现实描述（卷积偶极子层）和对其时间活动的生理学相关描述（耦合神经元群）。该模型用于癫痫样活动（间歇峰）的特定背景下，以解释同时生成的头皮和脑内脑电图。它的综合特性允许在与源相关的参数（空间范围、位置、同步）和产生的EEG信号的特性（尖峰振幅、沿脑内电极的振幅梯度、头皮电极上的地形）之间架起桥梁。两种记录方式对源相关参数的敏感性也进行了研究。该模型证实，与间歇峰有关的皮质区域相当大。它相对于记录电极的相对位置对脑电图信号的性质有很大的影响，因为源的几何形状是一个关键参数。研究了癫痫源内神经元群同步程度对模拟信号的影响。该模型表明，脑内脑电图可以反映癫痫斑块神经元群之间弱同步的癫痫活动。讨论了这些结果以及模型的局限性。(C) 2008爱思唯尔公司版权所有。
In many applications which make use of EEG to investigate brain functions, a central question is often to relate the recorded signals to the spatio-temporal organization of the underlying neuronal sources of activity. A modeling attempt to quantitatively investigate this imperfectly known relationship is reported. The proposed plausible model of EEG generation relies on an accurate representation of the neuronal sources of activity. It combines both an anatomically realistic description of the spatial features of the sources (convoluted dipole layer) and a physiologically relevant description of their temporal activities (coupled neuronal populations). The model was used in the particular context of epileptiform activity (interictal spikes) to interpret simultaneously generated scalp and intracerebral EEG. Its integrative properties allowed for the bridging between source-related parameters (spatial extent, location, synchronization) and the properties of resulting EEG signals (amplitude of spikes, amplitude gradient along intracerebral electrodes, topography over scalp electrodes). The sensitivity of both recording modalities to source-related parameters was also studied. The model confirmed that the cortical area involved in interictal spikes is rather large. Its relative location with respect to recording electrodes was found to strongly influence the properties of EEG signals as the source geometry is a critical parameter. The influence, on simulated signals, of the synchronization degree between neuronal populations within the epileptic source was also investigated. The model revealed that intracerebral EEG can reflect epileptic activities corresponding to weak synchronization between neuronal populations of the epileptic patch. These results, as well as the limitations of the model, are discussed. (C) 2008 Elsevier Inc. All rights reserved.