Established neointimal hyperplasia in vein grafts expands via TGF-β-mediated progressive fibrosis
Established neointimal hyperplasia in vein grafts expands via TGF-β-mediated progressive fibrosis
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DOI：
10.1152/ajpheart.00268.2009
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发表时间：
2009-10-01
影响因子：
4.8
通讯作者：
Berceli, Scott A.
中科院分区：
文献类型：
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作者：
Jiang, Zhihua;Tao, Ming;Berceli, Scott A.
Jiang Z，Tao M，Omalley KA，Wang D，Ozaki CK，Berceli SA.静脉移植物中已建立的新生内膜增生通过TGF-β介导的进行性纤维化扩展。美国生理学杂志心脏循环生理学297：H1200-H1207，2009年。首次发表于2009年7月17日; doi：10.1152/ajpheart.00268.2009。在植入后数周至数月内，静脉移植物（VG）中的新生内膜增生（NIH）从细胞化表型转变为脱细胞化表型。早期细胞增殖的抑制未能改善VG的长期通畅性。我们先前已经证明，转化生长因子-β（1）（TGF-β（1））/结缔组织生长因子（CTGF）途径介导了早期VG中成纤维细胞向肌成纤维细胞的转化（
Jiang Z, Tao M, Omalley KA, Wang D, Ozaki CK, Berceli SA. Established neointimal hyperplasia in vein grafts expands via TGF-beta-mediated progressive fibrosis. Am J Physiol Heart Circ Physiol 297: H1200-H1207, 2009. First published July 17, 2009; doi: 10.1152/ajpheart.00268.2009.-In weeks to months following implantation, neointimal hyperplasia (NIH) in vein grafts (VGs) transitions from a cellularized to a decellularized phenotype. The inhibition of early cellular proliferation failed to improve long-term VG patency. We have previously demonstrated that transforming growth factor-beta(1) (TGF-beta(1))/connective tissue growth factor (CTGF) pathways mediate a conversion of fibroblasts to myofibroblasts in the early VG (