The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy
The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy
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DOI：
10.1016/j.neubiorev.2018.08.014
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发表时间：
2020-03-01
影响因子：
8.2
通讯作者：
Cornish, Jennifer L.
中科院分区：
文献类型：
--
作者：
Baracz, Sarah J.;Everett, Nicholas A.;Cornish, Jennifer L.
幼年创伤与更易滥用非法药物和神经发育受损密切相关。这包括改变催产素系统的发展，催产素系统在调节社会行为和情绪方面起着关键作用。这一重要系统的调节失调也会导致药物成瘾的易感性增加。在这篇综述中，我们提供了一个概述的早期生活压力的动物模型，被广泛使用，并讨论了早期生活压力的影响，在青春期和成年期的吸毒行为在两性。我们将其与早期生活压力对内源性催产素系统的变化以及外源性催产素如何有助于重建系统功能，从而减少吸毒行为联系起来。
Early life trauma is strongly associated with an increased vulnerability to abuse illicit drugs and the impairment of neural development. This includes alterations to the development of the oxytocin system, which plays a pivotal role in the regulation of social behaviours and emotion. Dysregulation of this important system also contributes to increased susceptibility to develop drug addiction. In this review, we provide an overview of the animal models of early life stress that are widely used, and discuss the impact that early life stress has on drug taking behaviour in adolescence and adulthood in both sexes. We link this to the changes that early life stress has on the endogenous oxytocin system, and how exogenously administered oxytocin may help to re-establish functioning of the system, and in turn, reduce drug-taking behaviour.