Sustained facilitatory action of FK960 on hippocampal neurotransmission
Sustained facilitatory action of FK960 on hippocampal neurotransmission
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FK960 对海马神经传递的持续促进作用
DOI：
10.1016/s0006-8993(99)02470-1
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发表时间：
2000
期刊：
影响因子：
2.9
通讯作者：
T. Nishizaki
中科院分区：
文献类型：
--
作者：
S. Matsuyama;T. Nomura;T. Nishizaki
本研究探讨了抗痴呆药物N-（4-乙酰基-1-哌嗪基）-对氟苯甲酰胺一水合物（FK 960）对海马神经传递的影响。在10 nM至10 μM浓度范围内，FK 960以钟形剂量依赖性方式增加大鼠海马脑片颗粒细胞层的群体峰电位（PS）振幅。在完整的小鼠海马中发现了类似的增强作用，注射后120 min作用仍然明显;在0.3 - 5 mg/kg浓度范围内，3 mg/kg FK 960腹腔注射获得最大效应。FK 960诱导的易化作用并不能阻断强直刺激诱导的增强作用。本研究的结果表明，FK 960诱导海马神经传递的一个持久的易化，但通过一个独立的强直性长时程增强的机制。这可以解释FK 960的记忆增强作用。
The present study investigated the effect of N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate (FK960), a piperazine derivative developed as antidementia drug, on hippocampal neurotransmission. FK960 increased the amplitude of population spikes (PSs) from the granular cell layer in rat hippocampal slices in a bell-shaped dose-dependent manner at concentrations ranged from 10 nM to 10 μM. A similar potentiation was found in the intact mouse hippocampus, the action being still evident 120 min after injection; a maximal effect was obtained with 3 mg/kg intraperitoneal injection of FK960 at concentrations ranged from 0.3 to 5 mg/kg. The facilitatory action induced by FK960 did not occlude the potentiation induced by tetanic stimulation. The results of the present study indicate that FK960 induces a long-lasting facilitation of hippocampal neurotransmission, but by a mechanism independent of the tetanic long-term potentiation. This may account for the memory enhancing action of FK960.