Biodegradable electrospun fibers for drug delivery
Biodegradable electrospun fibers for drug delivery
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DOI：
10.1016/s0168-3659(03)00372-9
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发表时间：
2003-10-30
影响因子：
10.8
通讯作者：
Jing, XB
中科院分区：
文献类型：
--
作者：
Jing, Z;Xu, XY;Jing, XB
通过在聚L-乳酸（PLLA）溶液中添加不同的表面活性剂（阳离子、阴离子和非离子）和典型药物，研究了表面活性剂和药物对PLLA静电纺丝纤维直径大小和均匀性的影响。观察到显著的直径减小和均匀性改善。结果表明，药物被包裹在纤维内部，在蛋白酶K存在下，由于PLLA纤维的降解，药物释放遵循近零级动力学。这种含有药物的超细纤维垫可能在未来找到临床应用。(C)2003 Elsevier B. V.保留所有权利。
The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future. (C) 2003 Elsevier B.V. All rights reserved.