Influence of 15 retinoic acid amides on urinary bladder carcinogenesis in the mouse.
Influence of 15 retinoic acid amides on urinary bladder carcinogenesis in the mouse.
复制标题
15种视黄酸酰胺对小鼠膀胱癌发生的影响。
DOI：
10.1093/carcin/3.12.1469
复制
发表时间：
1982
期刊：
影响因子：
4.7
通讯作者：
Sporn,MB
中科院分区：
文献类型：
--
作者：
Moon,RC;McCormick,DL;Becci,PJ;Shealy,YF;Frickel,F;Paust,J;Sporn,MB
A series of experiments was conducted to determine the efficacy of 15 synthetic retinoic acid amides (retinamides) as inhibitors of chemical carcinogenesis of the urinary bladder in C57BL/6 × DBA/2F1mice. Eight of the retinamides tested had significant protective activity when administered at non-toxic levels in the diet. Minor structural alterations, such as the addition of a methyl or hydroxyl group to the terminal amide moiety had a major influence on the anticarcinogenic activity of the retinamides. Although 13-cisretinamides generally were less toxic on a molar basis than were their all-transisomers, no consistent pattern of differential anticarcinogenic activity was noted among the six pairs of all-trans and 13-cisisomers tested. All-trans-4-hydroxyphenyl retinamide was among the most active and least toxic of the retinoids tested, and appears to be the compound of choice for further study.
