Mitigation of hookworm disease by immunization with soluble extracts of Ancylostoma ceylanicum
Mitigation of hookworm disease by immunization with soluble extracts of Ancylostoma ceylanicum
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DOI：
10.1086/319867
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发表时间：
2001-05-01
影响因子：
6.4
通讯作者：
Cappello, M
中科院分区：
文献类型：
--
作者：
Bungiro, RD;Greene, J;Cappello, M
钩虫是发展中国家贫血的主要原因，旨在减少吸血成虫寄生虫引起的病理学的战略将是对全球控制工作的宝贵补充。本文介绍了实验设计，以诱导抗性的主要临床后遗症（体重减轻和贫血）的Ancylostoma ceylanicum钩虫感染叙利亚金黄仓鼠的远交LVG株。先前感染的动物获得了对继发性钩虫感染引起的体重减轻和贫血的长期抵抗力。此外，从两次感染的仓鼠转移到动物的合并血清经历的主要感染与部分抵抗生长延迟和贫血。主动接种仓鼠可溶性成人钩虫抗原乳化在明矾导致部分保护钩虫相关的病理在没有减少成虫负担。这一有趣的结果可能对人类疫苗的开发具有重要意义。
Hookworms are a leading cause of anemia in developing countries, and a strategy aimed at reducing pathology caused by blood-feeding adult parasites would be a valuable addition to global control efforts. This article describes experiments designed to induce resistance to the major clinical sequelae (weight loss and anemia) of Ancylostoma ceylanicum hookworm infection in Syrian golden hamsters of the outbred LVG strain. Previously infected animals acquired long-lived resistance to weight loss and anemia caused by a secondary hookworm infection. Furthermore, transfer of pooled serum from twice-infected hamsters to animals undergoing a primary infection was associated with partial resistance to growth delay and anemia. Active vaccination of hamsters with soluble adult hookworm antigens emulsified in alum led to partial protection from hookworm-associated pathology in the absence of reductions in adult worm burden. This intriguing result may have important implications for human vaccine development.