Reward Network Immediate Early Gene Expression in Mood Disorders.
Reward Network Immediate Early Gene Expression in Mood Disorders.
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DOI：
10.3389/fnbeh.2017.00077
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发表时间：
2017
影响因子：
3
通讯作者：
Robison AJ
中科院分区：
文献类型：
--
作者：
Manning CE;Williams ES;Robison AJ
在过去的三十年里，人们已经清楚地认识到，负责奖励处理和动机行为的相互连接的大脑区域网络的异常功能是各种情绪障碍（包括抑郁和焦虑）的基础。同样清楚的是，压力引起的正常和病理行为背后的奖赏网络活动的变化也会引起基因表达的变化。在这里，我们试图定义奖励回路，并探索该回路内活动依赖性基因表达变化对压力引起的情绪障碍行为变化的已知和潜在贡献，并将其中一些影响与暴露于滥用药物引起的影响进行对比。我们重点关注该回路内一系列受压力调节的早期基因及其与回路功能和随后的奖励相关行为的联系，这些基因都是经过充分探索且相对新颖的。我们得出的结论是，IEG 在应激依赖性奖赏回路重塑中发挥着至关重要的作用，并且它们可能有助于情绪障碍病因学和治疗的分子、细胞和回路水平机制。
Over the past three decades, it has become clear that aberrant function of the network of interconnected brain regions responsible for reward processing and motivated behavior underlies a variety of mood disorders, including depression and anxiety. It is also clear that stress-induced changes in reward network activity underlying both normal and pathological behavior also cause changes in gene expression. Here, we attempt to define the reward circuitry and explore the known and potential contributions of activity-dependent changes in gene expression within this circuitry to stress-induced changes in behavior related to mood disorders, and contrast some of these effects with those induced by exposure to drugs of abuse. We focus on a series of immediate early genes regulated by stress within this circuitry and their connections, both well-explored and relatively novel, to circuit function and subsequent reward-related behaviors. We conclude that IEGs play a crucial role in stress-dependent remodeling of reward circuitry, and that they may serve as inroads to the molecular, cellular, and circuit-level mechanisms of mood disorder etiology and treatment.