Emergence of delayed behavioral effects in offspring mice exposed to low levels of mercury vapor during the lactation period.
Emergence of delayed behavioral effects in offspring mice exposed to low levels of mercury vapor during the lactation period.
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DOI：
10.2131/jts.38.1
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发表时间：
2013-02
期刊：
影响因子：
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通讯作者：
Minoru Yoshida;C. Watanabe;Akiko Honda;M. Satoh;A. Yasutake
中科院分区：
文献类型：
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作者：
Minoru Yoshida;C. Watanabe;Akiko Honda;M. Satoh;A. Yasutake
本研究考察了在哺乳期暴露于低水平汞蒸气 (Hg(0)) 的子代小鼠的延迟行为效应的出现。雌性小鼠后代重复暴露于 0.057 mg/m(3) 的 Hg(0) 环境中，与当前阈值 (TLV) 相似，持续 24 小时，直至产后第 20 天。 3个月和15个月时，通过旷场运动活动（OPF）、被动回避反应（PA）学习活动和莫里斯水迷宫（MM）空间学习能力来评估行为效果。 Hg(0) 暴露小鼠在 3 个月龄时的三项行为测量中与对照组没有差异，并且没有观察到神经行为影响。另一方面，在 15 个月大时进行测试时，小鼠在 OPF 任务中表现出明显更多的中枢运动，但其他行为表现没有异常。出生后立即暴露后，子代的脑汞浓度约为对照的150倍，浓度约为0.4微克/克。结果表明，在发育期间暴露于 TLV 左右浓度的 Hg(0) 的小鼠会导致在生命后期出现延迟行为效应。
This study examined the emergence of delayed behavioral effects in offspring mice exposed to low levels of mercury vapor (Hg(0)) during the lactation period. Female offspring of mice were repeatedly exposed to Hg(0) at 0.057 mg/m(3), similar to the current threshold value (TLV), for 24 hr until the 20(th) day postpartum. The behavioral effects were evaluated with locomotor activity in the open field (OPF), learning activity in the passive avoidance response (PA) and spatial learning ability in the Morris water maze (MM) at the ages of 3 and 15 months. Hg(0)-exposed mice did not differ from controls in the three behavioral measurements at 3 months of age, and no neurobehavioral effects were observed. On the other hand, the mice exhibited significantly more central locomotion in the OPF task when tested at 15 months of age, but no abnormality in other behavioral performance. Immediately after postnatal exposure, the brain mercury concentration of offspring was about 150 times that of the control, in which the concentrations were approximately 0.4 µg/g. The results indicate that mice exposed to Hg(0) at concentrations around TLV during the developing period resulted in the emergence of delayed behavioral effects at a later stage in life.