Arousal Contributions to Resting-State fMRI Connectivity and Dynamics
Arousal Contributions to Resting-State fMRI Connectivity and Dynamics
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DOI：
10.3389/fnins.2019.01190
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发表时间：
2019-11-05
影响因子：
4.3
通讯作者：
Liu, Xiao
中科院分区：
文献类型：
--
作者：
Gu, Yameng;Han, Feng;Liu, Xiao
静息状态功能磁共振成像（rsfMRI）被广泛用于绘制健康和患病大脑的连接和动态图。然而，静息状态范式允许大脑觉醒的不受约束的波动，这可能对静息状态fMRI信号和相关的连通性/动态指标产生深远影响。在这里，我们回顾了目前对静息状态fMRI和大脑觉醒之间关系的理解，特别是最近发现的觉醒调节事件对静息状态fMRI的影响。我们进一步讨论了唤醒相关fMRI调制的潜在含义，重点关注其在调节静息状态连接/动态与生理和行为之间的虚假相关性方面的潜在作用。根据现有证据提出了多个假设，并有待未来研究的检验。
Resting-state functional magnetic resonance imaging (rsfMRI) is being widely used for charting brain connectivity and dynamics in healthy and diseased brains. However, the resting state paradigm allows an unconstrained fluctuation of brain arousal, which may have profound effects on resting-state fMRI signals and associated connectivity/dynamic metrics. Here, we review current understandings of the relationship between resting-state fMRI and brain arousal, in particular the effect of a recently discovered event of arousal modulation on resting-state fMRI. We further discuss potential implications of arousal-related fMRI modulation with a focus on its potential role in mediating spurious correlations between resting-state connectivity/dynamics with physiology and behavior. Multiple hypotheses are formulated based on existing evidence and remain to be tested by future studies.