Correlation of acoustic threshold measures and spiral ganglion cell survival in severe to profound sensorineural hearing loss: Implications for cochlear implantation
Correlation of acoustic threshold measures and spiral ganglion cell survival in severe to profound sensorineural hearing loss: Implications for cochlear implantation
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DOI：
10.1177/000348949810701102
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发表时间：
1998-11-01
影响因子：
1.4
通讯作者：
Nadol, JB
中科院分区：
文献类型：
--
作者：
Incesulu, A;Nadol, JB
在一项对13例重度感音神经性听力损失患者的26只耳的颞骨研究中，节段性和总螺旋神经节细胞（SGC）计数与听力阈值、两耳听力阈值差异、死亡年龄、耳聋持续时间和听力损失持续时间相关。总SGC计数的耳间差异与3、4、5个频率的纯音平均值的耳间差异之间存在统计学上显著的相关性。12例患者中有11例耳内SGC总计数较高，残听较好。纯音平均耳际差异的变异约有41%可以用SGC计数的差异来解释。研究结果表明，在一个特定的个体中，选择残余听力较好的耳朵进行人工耳蜗植入可能会导致获得更多的残余SGCs。反过来，这可能会导致植入物更好的语音识别。
In a temporal bone study of 26 ears from 13 patients who, in life, had severe sensorineural hearing loss, the segmental and total spiral ganglion cell (SGC) counts were correlated with hearing thresholds and with the difference between hearing thresholds in the two ears, the age at death, the duration of deafness, and the duration of hearing loss. A statistically significant correlation was found between the interaural differences in total SGC counts and the interaural difference in pure tone averages for 3, 4, and 5 frequencies. The total SGC count was higher in the ear with the better residual hearing in 11 of 12 cases. Approximately 41% of the variability in interaural difference in pure tone average was explained by the difference in SGC counts. The findings would suggest that in a given individual, selection of the ear with better residual hearing for cochlear implantation is likely to result in accessing a higher number of residual SGCs. This, in turn, may result in better speech recognition with the implant.