Love hurts: An fMRI study
Love hurts: An fMRI study
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DOI：
10.1016/j.neuroimage.2010.02.047
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发表时间：
2010-06-01
期刊：
影响因子：
5.7
通讯作者：
Decety, Jean
中科院分区：
文献类型：
--
作者：
Cheng, Yawei;Chen, Chenyi;Decety, Jean
亲密的关系对人类的生存是至关重要的。这种亲密可以被描述为在自我中包括他人，并建立在社会依恋系统上，社会依恋系统是从伤害性机制的重定向进化而来的。想象一个心爱的人和想象一个陌生的人处于痛苦的境地有多大的不同？在这项功能磁共振研究中，参与者被暴露在描绘痛苦和非痛苦情况下的手或脚的动画刺激中，并被指示从三个不同的角度想象这些场景：自我、所爱的人和陌生人，在接受了各自的照片准备后。与之前的研究一致，这三个观点与涉及疼痛处理的神经网络的激活有关。具体地说，采用亲人的视角会增加前扣带皮质和脑岛的活动，而想象陌生人会导致右侧颞顶交界处(TPJ)和额叶上回的信号增加。参与者与其伴侣的关系越密切，右侧TPJ的失活程度就越大。当参与者想象陌生人的视角时，发现右侧顶盖和脑岛之间的有效连接是负的，而与额上回之间的连接是正的。这些结果表明，亲密性影响了与共情有关的自下而上的信息处理，正如自我和他人的神经表征之间更大的重叠所表明的那样。(C)2010 Elsevier Inc.保留所有权利。
Being in a close relationship is essential to human existence. Such closeness can be described as including other in the self and be underpinned on social attachment system, which evolved from a redirection of nociceptive mechanisms. To what extent does imagining a loved-one differs from imagining an unfamiliar individual being in painful situations? In this functional MRI study, participants were exposed to animated stimuli depicting hands or feet in painful and non-painful situations, and instructed to imagine these scenarios from three different perspectives: self, loved-one and stranger after being primed with their respective photographs. In line with previous studies, the three perspectives were associated with activation of the neural network involved in pain processing. Specifically, adopting the perspective of a loved-one increased activity in the anterior cingulate cortex and insula, whereas imagining a stranger induced a signal increase in the right temporo-parietal junction (TPJ) and superior frontal gyrus. The closer the participants' relationships were with their partner, the greater the deactivation in the right TPJ. A negative effective connectivity between the right TPJ and the insula, and a positive one with the superior frontal gyrus were found when participants imagined the perspective of a stranger. These results demonstrate that intimacy affects the bottom-up information processing involved in empathy, as indicated by greater overlap between neural representations of the self and the other. (C) 2010 Elsevier Inc. All rights reserved.