Decrypting the genome's alternative messages
Decrypting the genome's alternative messages
复制标题
DOI：
10.1016/j.ceb.2009.02.006
复制
发表时间：
2009-06-01
影响因子：
7.5
通讯作者：
Valcarcel, Juan
中科院分区：
文献类型：
--
作者：
Hartmann, Britta;Valcarcel, Juan
信使RNA （mRNA）前体的选择性剪接影响大多数人类基因，对真核生物基因功能有相当大的影响，并为调控提供了独特的机会。选择性剪接的改变可以引起或改变许多病理的进展。最近的高通量技术已经揭示了由选择性剪接产生的丰富的转录本多样性，以及这种多样性如何建立和变得失调的例子。从转录和mRNA编辑或衰变到基于mirna的调控和端粒酶功能，多种机制协调调节剪接位点的选择与其他细胞过程。选择性剪接研究有助于我们理解多种生物过程，包括遗传多样性、物种形成、细胞/干细胞分化、神经系统功能、神经肌肉疾病和肿瘤进展。
Alternative splicing of messenger RNA (mRNA) precursors affects the majority of human genes, has a considerable impact on eukaryotic gene function and offers distinct opportunities for regulation. Alterations in alternative splicing can cause or modify the progression of a significant number of pathologies. Recent high-throughput technologies have uncovered a wealth of transcript diversity generated by alternative splicing, as well as examples for how this diversity can be established and become misregulated. A variety of mechanisms modulate splice site choice coordinately with other cellular processes, from transcription and mRNA editing or decay to miRNA-based regulation and telomerase function. Alternative splicing studies can contribute to our understanding of multiple biological processes, including genetic diversity, speciation, cell/stem cell differentiation, nervous system function, neuromuscular disorders and tumour progression.