EFFECT OF EXCESS ENDOGENOUS ANDROGENS ON BONE-DENSITY IN YOUNG-WOMEN
EFFECT OF EXCESS ENDOGENOUS ANDROGENS ON BONE-DENSITY IN YOUNG-WOMEN
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DOI：
10.1210/jcem-67-5-937
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发表时间：
1988-11-01
影响因子：
5.8
通讯作者：
DEMERS, LM
中科院分区：
文献类型：
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作者：
BUCHANAN, JR;HOSPODAR, P;DEMERS, LM
为了确定内源性雄激素是否影响年轻女性的骨密度，我们研究了27名正常女性和19名雄激素过多的女性，如血清生物可利用睾酮（bioT）浓度增加所定义的。这些妇女的年龄范围为21-48岁。两组在年龄、拟人测量、营养、妇科病史、血清皮质醇和雌二醇水平方面具有可比性。分别通过计算机断层扫描和单光子吸收测定法对小梁（腰椎）和皮质（桡骨）骨密度进行定量。测定在周期的卵泡期期间获得的血清的生物T、总T、硫酸脱氢表雄酮、雄烯二酮（Adione）和3 α-雄甾烷葡糖苷酸（3-Adiol-G）。雄激素过多组的松质骨密度显著较高[172 . ±. 7（.+-. SE）vs. 153 .+-. 5 mg/mL; P = 0.03];对照血清腺苷二酮（但不对照血清生物T、总T、硫酸脱氢表雄酮或3 α-脱氢表雄酮）。雄甾烷葡糖苷酸或3-Adiol-G）消除了这种差异。同样，血清雄激素与骨小梁密度的相关性也比其他雄激素更强（r = 0.31; P = 0.03）。雄激素过多组的平均皮质骨密度并不高（0.740 ± 0.001）。0.014对0.722 ±。0.008 g/cm 2; P = 0.27）。在27名正常女性中，皮质密度与血清生物T（r = 0.47; P = 0.01）和总T（r = 0.53; P = 0.004）相关，但与其他雄激素无关。我们的结论是内源性雄激素的超生理水平与年轻女性骨小梁密度增加有关。血清雄酮似乎是雄激素对小梁密度影响的最佳标志物。在正常妇女中，皮质骨密度与血清T有关。
To determine whether endogenous androgens influence bone density in young women, we studied 27 normal women and 19 women with androgen excess, as defined by increased serum bioavailable testosterone (bio T) concentrations. The women ranged from 21-48 yr of age. The 2 groups were comparable with respect to age, anthropomorphic measures, nutrition, gynecological history, and serum cortisol and estradiol levels. Trabecular (lumbar) and cortical (radial) bone density were quantitated by computerized tomography and single photon absorptiometry, respectively. Serum obtained during the follicular phase of the cycle was assayed for bio T, total T, dehydroepiandrosterone sulfate, androstenedione (Adione), and 3.alpha.-androstanediol glucuronide (3-Adiol-G). Trabecular bone density was significantly higher in the androgen excess group [172 .+-. 7 (.+-. SE) vs. 153 .+-. 5 mg/mL; P = 0.03]; controlling for serum Adione (but not for serum bio T, total T, dehydroepiandrosterone sulfate, or 3.alpha.-androstanediol glucuronide, or 3-Adiol-G) abolished this difference. Similarly, serum Adione correlated more strongly than the other androgens with trabecular bone density (r = 0.31; P = 0.03). Average cortical bone density was not higher in the androgen excess group (0.740 .+-. 0.014 vs. 0.722 .+-. 0.008 g/cm2; P = 0.27). Among the 27 normal women, cortical density was correlated to serum bio T (r = 0.47; P = 0.01) and total T (r = 0.53; P = 0.004), but not to the other androgens. We conclude that supraphysiological levels of endogenous androgens are associated with increased trabecular bone density in young women. Serum Adione appeared to be the best marker for the impact of androgen on trabecular density. Among normal women, cortical bone density was related to serum T.