Effects of tributyltin on early life-stage, reproduction, and gonadal sex differentiation in Japanese medaka (Oryzias latipes).
Effects of tributyltin on early life-stage, reproduction, and gonadal sex differentiation in Japanese medaka (Oryzias latipes).
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DOI：
10.1016/j.chemosphere.2018.03.135
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发表时间：
2018-07
期刊：
影响因子：
8.8
通讯作者：
Y. Horie;Takahiro Yamagishi;Yoko Shintaku;T. Iguchi;N. Tatarazako
中科院分区：
文献类型：
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作者：
Y. Horie;Takahiro Yamagishi;Yoko Shintaku;T. Iguchi;N. Tatarazako
三丁基锡是一种有机锡化合物，作为水生环境的防污剂在世界范围内得到广泛应用，其毒理学和生态毒理学特性受到广泛关注。尽管三丁基锡已在世界范围内被禁止，但在水生环境中仍能检测到低浓度的三丁基锡。本研究研究了三丁基锡对日本稻（Oryzias latipes）早期生活阶段、生殖和性腺性别分化的影响。在成人中，暴露于3.82 μg/L的三丁基锡抑制了繁殖力和繁殖力，增加了死亡率。当浓度为10.48 μg/L时，暴露第6天所有水母死亡。早期暴露于三丁基锡对幼鼠的死亡率和胚胎发育没有显著影响，但暴露于0.13和0.68 μg/L组的生长受到抑制。此外，暴露于三丁基锡的日本medaka没有出现性腺发育异常。这些结果为三丁基锡对硬骨鱼繁殖的负面影响提供了证据。三丁基廷不影响日本medaka的性腺性别分化，但繁殖力和生育能力受到抑制，尽管这种抑制是由于三丁基廷的内分泌干扰作用还是其毒性尚不清楚。
Tributyltin, an organotin compound, was used worldwide as an antifouling agent in aquatic environments and there has been much concern about the toxicological and ecotoxicological properties of organotin compounds. Even though it has been prohibited worldwide, tributyltin is still detected at low concentrations in aquatic environments. Here we investigated the effects of tributyltin on the early life-stage, reproduction, and gonadal sex differentiation in Japanese medaka (Oryzias latipes). In adults, exposure to tributyltin at 3.82 μg/L suppressed fecundity and fertility and increased mortality. At 10.48 μg/L all medaka died by the sixth day of exposure. Exposure to tributyltin during early life-stages induced no significant differences in mortality or embryonic development, but growth was suppressed in groups exposed to 0.13 and 0.68 μg/L. Furthermore, there was no abnormal gonadal development in Japanese medaka exposed to tributyltin. These results provide evidence of the negative effects of tributyltin on reproduction in a teleost fish. Tributyltin did not affect gonadal sex differentiation in Japanese medaka, but fecundity and fertility were suppressed, although it is not clear whether this suppression resulted from the endocrine-disrupting action of tributyltin or its toxicity.