Acute interstitial pneumonitis caused by Aleutian disease virus in mink kits.
Acute interstitial pneumonitis caused by Aleutian disease virus in mink kits.
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水貂套件中阿留申病病毒引起的急性间质性肺炎。
DOI：
10.1111/j.1699-0463.1984.tb04419.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
M. Hansen
中科院分区：
文献类型：
--
作者：
S. Larsen;S. Alexandersen;E. Lund;P. Have;M. Hansen
在四个丹麦水貂牧场急性间质性肺炎造成过度死亡率在第一个2 1/2个月内分娩后的套件。这种疾病被发现是由于阿留申病毒（ADV），并可以复制实验在新生儿试剂盒接种材料从自发的情况下，以及与其他菌株的ADV。实验繁殖只可能在试剂盒从母鼠自由阿留申病（AD），而试剂盒从母鼠实验或自然感染ADV没有肺的变化。目前可用的证据表明，最初的肺部病变是由II型肺泡细胞的原发性病毒损伤引起的，并且对于传统AD的发展至关重要的免疫机制不参与发病机制。
In four Danish mink ranches acute interstitial pneumonitis caused excessive mortality among kits within the first 2 1/2 months after parturition. The disease was found to be due to an Aleutian disease virus (ADV) and could be reproduced experimentally in neonatal kits by inoculation with material from spontaneous cases, as well as with other strains of ADV. Experimental reproduction was only possible in kits from dams free of Aleutian disease (AD) whereas kits from dams experimentally or naturally infected with ADV developed no lung changes. Presently available evidence indicates that the initial lung lesions result from primary viral injury to type II alveolar cells, and that immune mechanisms, essential for the development of traditional AD, are not involved in the pathogenesis.