Mitochondrial Haplogroups N9 and G Are Associated with Metabolic Syndrome Among Human Immunodeficiency Virus-Infected Patients in China
Mitochondrial Haplogroups N9 and G Are Associated with Metabolic Syndrome Among Human Immunodeficiency Virus-Infected Patients in China
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线粒体单倍群 N9 和 G 与中国人类免疫缺陷病毒感染患者的代谢综合征相关
DOI：
10.1089/aid.2018.0151
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发表时间：
2019
影响因子：
1.5
通讯作者：
Na He
中科院分区：
文献类型：
--
作者：
Dan Zhao;Yingying Ding;Haijiang Lin;Xiaoxiao Chen;Weiwei Shen;Meiyang Gao;Qian Wei;Sujuan Zhou;Xing Liu;Na He
越来越多的证据表明，线粒体DNA （mtDNA）变异对代谢紊乱有重要影响，但这类研究尚未在亚洲的艾滋病毒感染患者中进行。我们研究了hiv感染患者mtDNA单倍群的分布及其与代谢紊乱的相关性。对中国东部某农村地区年龄在40岁以上的296例HIV患者进行了横断面调查。使用标准使用的四对重叠引物，通过聚合酶链反应扩增整个mtDNA序列。在该样本中，mtDNA单倍群B、D、M7和F是最占优势的单倍群。代谢综合征（MetS）的总体患病率为36.1%，其中单倍群G最高（77.8%），单倍群M8最低（21.4%）。在多变量分析中，单倍群G和N9与MetS的存在显著相关[校正优势比(aOR) = 13.5, 95%可信区间（CI）： 1.9-94.7；aOR = 8.1, 95% CI: 1.8 ~ 36.1；分别)。此外，单倍群G患者糖化血红蛋白（HbA1c）升高的几率增加（aOR = 10.1, 95% CI: 1.4-71.1），单倍群N9患者甘油三酯升高的几率增加（aOR = 13.5, 95% CI: 2.4-76.8）。mtDNA单倍群与其他MetS成分之间无显著关联。我们的数据证明了mtDNA单倍群与hiv感染患者的MetS之间的关联。亚洲特有的mtDNA单倍群G和N9可能会增加hiv感染患者发生MetS的风险，这需要进一步的纵向研究。
Increasing evidence shows that mitochondrial DNA (mtDNA) variations have an important effect on metabolic disorders, but such studies have not been conducted in HIV-infected patients in Asia. We investigated the distribution of mtDNA haplogroups and their correlation with metabolic disorders in HIV-infected patients. A cross-sectional survey was performed among 296 HIV patients older than the age of 40 years in a rural prefecture, Eastern China. The entire mtDNA sequence was amplified by polymerase chain reaction using four overlapping pairs of primers that have been standardly used. In this sample, mtDNA haplogroups B, D, M7, and F were the most dominant haplogroups. The overall prevalence of metabolic syndrome (MetS) was 36.1%, and was highest (77.8%) among those with haplogroup G and lowest (21.4%) among those with haplogroup M8. In multivariable analysis, haplogroups G and N9 were significantly associated with the presence of MetS [adjusted odds ratio (aOR) = 13.5, 95% confidence interval (CI): 1.9–94.7; aOR = 8.1, 95% CI: 1.8–36.1; respectively]. Moreover, patients with haplogroup G had increased odds of elevated glycated hemoglobin (HbA1c) (aOR = 10.1, 95% CI: 1.4–71.1), patients with haplogroup N9 had increased odds of elevated triglycerides (aOR = 13.5, 95% CI: 2.4–76.8). No significant association between mtDNA haplogroups and other MetS components was observed. Our data demonstrate the association between mtDNA haplogroups and MetS in HIV-infected patients. The Asian-specific mtDNA haplogroups G and N9 may confer higher risk for the development of MetS in HIV-infected patients, which requires further longitudinal investigation.