A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices
A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices
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DOI：
10.1039/c3cc42037j
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Paradossi, Gaio
中科院分区：
文献类型：
--
作者：
Capece, Sabrina;Chiessi, Ester;Paradossi, Gaio
多功能超声造影剂(UCAS)的制备最近受到多个研究小组的关注。描述了一种以生物可降解囊泡的形式合成具有生物相容的交联型聚合物壳的UCA前体的通用策略。在超声波辐射下，声学液滴汽化将这些颗粒转化为表现为Ucas的微泡。这种概念的证明需要潜在的治疗微设备的特征。
Fabrication of multifunctional ultrasound contrast agents (UCAs) has been recently addressed by several research groups. A versatile strategy for the synthesis of UCA precursors in the form of biodegradable vesicles with a biocompatible crosslinked polymer shell is described. Upon ultrasound irradiation, acoustic droplet vaporization transforms such particles into microbubbles behaving as UCAs. This proof of concept entails the features of a potential theranostic microdevice.