Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date.
Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date.
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DOI：
10.1007/s40263-016-0313-z
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发表时间：
2016-02
期刊：
影响因子：
6
通讯作者：
Leggio L
中科院分区：
文献类型：
--
作者：
Lee MR;Rohn MC;Tanda G;Leggio L
神经肽催产素在奖励、压力、社会关系、学习和记忆过程中发挥作用。因此，催产素作为成瘾的潜在治疗方法越来越受到关注。催产素系统本身也会因急性或慢性药物滥用而改变。在啮齿动物中进行的大量临床前研究已经调查了催产素对各种药物诱导行为的影响，以确定催产素是否可以逆转重复使用药物和酒精时发生的神经适应。此外，催产素改变对滥用药物的行为反应的机制也开始被理解。最近，对可卡因、大麻和酒精依赖进行了一些小型临床研究。本文综述了迄今为止关于催产素系统及其与药物和酒精成瘾的相关性的临床前和临床文献。
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning and memory processes. As such there is increasing interest in oxytocin as a potential treatment for addictions. The oxytocin system is itself altered by acute or chronic exposure to drugs of abuse. A large number of preclinical studies in rodents have investigated the effect of oxytocin on various drug-induced behaviors to determine whether oxytocin can reverse the neuroadaptations occurring with repeated drug and alcohol use. In addition, the mechanisms by which oxytocin acts to modify the behavioral response to drugs of abuse are beginning to be understood. More recently, a few small clinical studies have been conducted in cocaine, cannabis and alcohol dependence. This review summarizes the preclinical as well as clinical literature to date on the oxytocin system and its relevance to drug and alcohol addiction.