Responses of group IV afferent units from skeletal muscle to stretch, contraction and chemical stimulation
Responses of group IV afferent units from skeletal muscle to stretch, contraction and chemical stimulation
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IV组骨骼肌传入单位对拉伸、收缩和化学刺激的反应
DOI：
10.1007/bf00239809
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发表时间：
1978
影响因子：
2
通讯作者：
R. Schmidt
中科院分区：
文献类型：
--
作者：
K. Kniffki;S. Mense;R. Schmidt
为了区分伤害性IV组肌肉受体和“角接受性”肌肉受体，研究了麻醉猫在局部压力、持续拉伸、重复收缩和动脉内注射缓激肽、5-羟色胺（5-HT）、钾、磷酸盐和乳酸时骨骼肌单组IV纤维的放电情况。在这项研究的75个纤维中，有5个单元被持续拉伸激活，反应出现延迟。这些拉伸敏感单元不能被局部压力或肌肉收缩激活。13例IV组传入神经在重复宫缩期间放电频率升高。有些单位在宫缩开始时立即作出反应，而其他单位则表现出明显的延迟。对46个单元进行了上述全部或大部分机械和化学刺激的测试。在32个事件中，至少存在对其中一个刺激的反应。仅考虑这些单位，几组受体可以通过其不同的反应组合来区分。一组被产生疼痛的物质激活，但不受肌肉活动的影响，因此表现出伤害性特征。另一组在肌肉收缩时表现出升高的活动，但对止痛剂缓激肽和5-羟色胺没有反应。属于这一组的单位可以作为“角质层受体”。两组之间的界限并不明显，有相当数量的第四组事件同时具有伤害性和“能受性”性质。
SummaryIn an attempt to differentiate between nociceptive group IV muscle receptors and “ergoceptive” ones, the discharges of single group IV fibres from skeletal muscle in response to local pressure, sustained stretch, repetitive contraction and intra-arterial injections of bradykinin, 5-hydroxytryptamine (5-HT), potassium, phosphate, and lactate were studied in anaesthetized cats.Of the 75 fibres of the study, 5 units were activated by sustained stretch, the responses occurring with a delay. These stretch-sensitive units could not be activated by local pressure or muscular contraction. Thirteen group IV afferents raised their discharge frequency during repetitive contractions. Some of the units responded immediately with the onset of the contractions, whereas the others showed a pronounced delay.Forty-six units were tested with all or most of the above mechanical and chemical stimuli. In 32 afferents a response to at least one of the stimuli was present. Taking only these units into account, several groups of receptors could be distinguished by their different response combinations. One group was activated by pain-producing substances, but not by muscular activity and thus showed nociceptive properties. Another group showed a raised activity during muscular contractions but did not respond to the algesic agents bradykinin and 5-HT. Units belonging to this group might serve as “ergoceptors”. The borderline between the two groups was not sharp, a considerable number of group IV afferents was found which had both nociceptive and “ergoceptive” properties.