Obesity and Its Impact on Transplantation and Alloimmunity
Obesity and Its Impact on Transplantation and Alloimmunity
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DOI：
10.1097/tp.0b013e3182869d2f
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发表时间：
2013-07-15
期刊：
影响因子：
6.2
通讯作者：
Tullius, Stefan G.
中科院分区：
文献类型：
--
作者：
Heinbokel, Timm;Floerchinger, Bernhard;Tullius, Stefan G.
肥胖已成为全球医疗保健中日益严重的问题，并产生了深远的影响。更多患有不可逆终末期器官衰竭的肥胖患者接受器官移植，并且更频繁地使用来自肥胖供体的器官。越来越多的证据表明，更频繁的术后并发症以及患者和移植物存活率的降低与肥胖有关。最近，脂肪组织与慢性炎症过程有关，可能影响同种免疫反应和移植物质量。
Obesity has become an increasing problem in healthcare worldwide with far-reaching consequences. More obese patients with irreversible end-stage organ failure undergo organ transplantation, and organs from obese donors are more frequently used. A growing body of evidence suggests more frequent postoperative complications and inferior patient and graft survival linked to obesity. More recently, adipose tissue has been linked to chronic inflammatory processes potentially impacting alloimmune responses and graft quality.