In vivo human crystalline lens topography.
In vivo human crystalline lens topography.
复制标题
体内人类晶状体形貌。
DOI：
10.1364/boe.3.002471
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发表时间：
2012-10-01
影响因子：
3.4
通讯作者：
Marcos S
中科院分区：
文献类型：
--
作者：
Ortiz S;Pérez-Merino P;Gambra E;de Castro A;Marcos S
定制的高分辨率高速眼前节光谱域光学相干断层扫描（OCT）被用来表征三维（3-D）的人体晶体透镜在体内。该系统配备了用于图像去噪和分割以及扇形（扫描）和光学（屈光）畸变校正的自定义算法，以提供晶状体透镜前表面和后表面的完全定量图像。该方法进行了测试的人工眼与已知的表面几何形状和人体透镜在体外，并证明在三个人体晶状体在体内。不校正畸变会高估前透镜半径25%，高估后透镜半径65%以上。在体透镜表面经畸变校正后分别用双锥面和Zernike多项式拟合。前透镜曲率半径范围为10.27 - 14.14 mm，后透镜曲率半径范围为6.12 - 7.54 mm。表面非球面度范围为-0.04--1.96。透镜表面很好地拟合二次曲面（对于5 mm瞳孔，变化小于2%），具有少量高阶项。表面透镜散光显著，前透镜通常显示水平散光（范围为−11至−1 µm），后透镜显示垂直散光（范围为6至10 µm）。
Custom high-resolution high-speed anterior segment spectral domain optical coherence tomography (OCT) was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo. The system was provided with custom algorithms for denoising and segmentation of the images, as well as for fan (scanning) and optical (refraction) distortion correction, to provide fully quantitative images of the anterior and posterior crystalline lens surfaces. The method was tested on an artificial eye with known surfaces geometry and on a human lens in vitro, and demonstrated on three human lenses in vivo. Not correcting for distortion overestimated the anterior lens radius by 25% and the posterior lens radius by more than 65%. In vivo lens surfaces were fitted by biconicoids and Zernike polynomials after distortion correction. The anterior lens radii of curvature ranged from 10.27 to 14.14 mm, and the posterior lens radii of curvature ranged from 6.12 to 7.54 mm. Surface asphericities ranged from −0.04 to −1.96. The lens surfaces were well fitted by quadrics (with variation smaller than 2%, for 5-mm pupils), with low amounts of high order terms. Surface lens astigmatism was significant, with the anterior lens typically showing horizontal astigmatism ( ranging from −11 to −1 µm) and the posterior lens showing vertical astigmatism ( ranging from 6 to 10 µm).