Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer.
Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer.
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DOI：
10.1186/s12957-021-02319-x
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发表时间：
2021-07-06
影响因子：
3.2
通讯作者：
Yoshimoto T
中科院分区：
文献类型：
--
作者：
Nishi M;Shimada M;Tokunaga T;Higashijima J;Yoshikawa K;Kashihara H;Takasu C;Ishikawa D;Wada Y;Eto S;Yoshimoto T
淋巴细胞与C反应蛋白（CRP）的比值（LCR）是全身炎症和宿主-肿瘤细胞相互作用的指标。本研究的目的是探讨LCR在接受术前放化疗（CRT）的低位直肠癌患者中的预后意义。本研究纳入了48例接受CRT治疗后接受根治性手术的低位直肠癌患者。分别于CRT治疗前后进行血常规检查，计算CRT治疗前后LCR。使用中位LCR将患者分为低LCR组和高LCR组进行分析。回顾性研究CRT前后LCR与临床结局的相关性。CRT前LCR明显高于CRT后LCR（分别为11、765和6780，P < 0.05）。CRT后LCR高者5年总生存率明显高于LCR低者（分别为90.6%和65.5%，P < 0.05）。在单变量分析中，CRT后LCR、CRT后中性粒细胞/淋巴细胞比率和fStage是总生存期的重要预后因素。多因素分析显示，CRT后LCR是影响总生存率的重要预后因素（P < 0.05），而其他临床病理因素和预后指标则无统计学意义。CRT后LCR可能是低位直肠癌患者的预后生物标志物。
The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host–tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients who received preoperative chemo-radiotherapy (CRT). Forty-eight patients with lower rectal cancer who underwent CRT followed by curative surgery were enrolled in this study. Routine blood examinations were performed before and after CRT were used to calculate pre-CRT LCR and post-CRT LCR. The median LCR was used to stratify patients into low and high LCR groups for analysis. The correlation between pre- and post-CRT LCR and clinical outcomes was retrospectively investigated. The pre-CRT LCR was significantly higher than the post-CRT LCR (11,765 and 6780, respectively, P < 0.05). The 5-year overall survival rate was significantly higher for patients with high post-CRT LCR compared with low post-CRT LCR (90.6% and 65.5%, respectively, P < 0.05). In univariate analysis, post-CRT LCR, post-CRT neutrophil to lymphocyte ratio, and fStage were significant prognostic factors for overall survival. In multivariate analysis, post-CRT LCR, but not other clinicopathological factors or prognostic indexes, was a significant prognostic factor for overall survival (P < 0.05). Post-CRT LCR could be a prognostic biomarker for patients with lower rectal cancer.
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影响因子：
3.2
作者：
Alsaif SH;Rogers AC;Pua P;Casey PT;Aherne GG;Brannigan AE;Mulsow JJ;Shields CJ;Cahill RA
通讯作者：
Cahill RA
影响因子：
28.4
作者：
Cercek, Andrea;Roxburgh, Campbell S. D.;Weiser, Martin R.
通讯作者：
Weiser, Martin R.
影响因子：
158.5
作者：
Sauer, R;Becker, H;Raab, R
通讯作者：
Raab, R
影响因子：
3.2
作者：
Paliogiannis, Panagiotis;Deidda, Simona;Zorcolo, Luigi
通讯作者：
Zorcolo, Luigi
影响因子：
3.8
作者：
Jansson, Hannes;Cornillet, Martin;Sparrelid, Ernesto
通讯作者：
Sparrelid, Ernesto