Multigenerational memory in bacterial size control
Multigenerational memory in bacterial size control
复制标题
细菌大小控制中的多代记忆
DOI：
10.1103/physreve.108.l032401
复制
发表时间：
2023
影响因子：
2.4
通讯作者：
Mugler, Andrew
中科院分区：
文献类型：
--
作者：
ElGamel, Motasem;Vashistha, Harsh;Salman, Hanna;Mugler, Andrew
细胞在生长和分裂时保持稳定的大小。受现有实验数据的启发，大多数提出的大小稳态模型假设大小控制机制作用于一代的时间尺度。此类机制导致尺寸波动的短暂自相关性，并在不到两代的时间内衰减。然而，最近比较姐妹谱系的证据表明，大小波动的相关性可以持续许多代。在这里，我们开发了一个最小模型来解释这些看似矛盾的结果。我们的模型提出，不同的环境会导致不同的控制参数，从而导致不同的继承模式。多代记忆在恒定的环境中被揭示出来，但在许多不同的环境中被平均化时被掩盖了。从微流控实验中的大肠杆菌数据推断我们的模型的参数，我们概括了观察到的统计。我们的论文阐明了环境对细胞稳态和生长分裂动力学的影响。
Cells maintain a stable size as they grow and divide. Inspired by the available experimental data, most proposed models for size homeostasis assume size-control mechanisms that act on a timescale of one generation. Such mechanisms lead to short-lived autocorrelations in size fluctuations that decay within less than two generations. However, recent evidence from comparing sister lineages suggests that correlations in size fluctuations can persist for many generations. Here we develop a minimal model that explains these seemingly contradictory results. Our model proposes that different environments result in different control parameters, leading to distinct inheritance patterns. Multigenerational memory is revealed in constant environments but obscured when averaging over many different environments. Inferring the parameters of our model fromEscherichia colisize data in microfluidic experiments, we recapitulate the observed statistics. Our paper elucidates the impact of the environment on cell homeostasis and growth and division dynamics.