Lipoprotein-associated phospholipase A2 and measures of extracoronary atherosclerosis - The Rotterdam study
Lipoprotein-associated phospholipase A2 and measures of extracoronary atherosclerosis - The Rotterdam study
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DOI：
10.1161/01.atv.0000201289.83256.cf
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发表时间：
2006-03-01
影响因子：
8.7
通讯作者：
Witteman, JCM
中科院分区：
文献类型：
--
作者：
Kardys, I;Oei, HHS;Witteman, JCM
目的：脂蛋白相关磷脂酶A2（Lp-PLA 2）可能是心血管事件的一个新的独立预测因子。Lp-PLA 2的作用可能通过酶对动脉粥样硬化发展的影响而发挥。因此，我们研究了脂蛋白-磷脂酶A2活性和测量冠状动脉外动脉粥样硬化之间的关联。方法和结果-脂蛋白-磷脂酶A2活性测定在随机抽样的1820名参与者的鹿特丹研究，一个基于人群的队列研究，男性和女性>= 55岁。检查颈总动脉内膜中层厚度、颈动脉斑块、踝臂指数和主动脉钙化。在1609名参与者中可以分配动脉粥样硬化状态。在任何部位，Lp-PLA 2活性最高与最低三分位数的动脉粥样硬化的年龄校正比值比在男性为1.86（95%CI，1.01至3.43），在女性为1.60（95%CI，1.08至2.37）。在额外调整胆固醇后，这些关联减弱甚至消失。在特定部位（颈动脉和腹髂股束）动脉粥样硬化的优势比遵循类似的pattern.Conclusions -虽然LP-PLA 2已被发现是独立相关的心血管事件，在这项研究中发现的亚临床冠状动脉外动脉粥样硬化的措施强烈衰减，甚至消失后调整胆固醇的关联。
Objective - Lipoprotein-associated phospholipase A2 ( Lp-PLA2) may be a new and independent predictor of cardiovascular events. The effect of Lp-PLA2 may be exerted through effects of the enzyme on the development of atherosclerosis. Therefore, we investigated the association between Lp-PLA2 activity and measures of extracoronary atherosclerosis.Methods and Results - Lp-PLA2 activity was determined in a random sample of 1820 participants from the Rotterdam Study, a population-based cohort study in men and women >= 55 years. Common carotid intima-media thickness, carotid plaques, ankle-arm index, and aortic calcification were examined. Atherosclerosis status could be assigned in 1609 participants. The age-adjusted odds ratio of having atherosclerosis at any site for the highest versus the lowest tertile of Lp-PLA2 activity was 1.86 ( 95% CI, 1.01 to 3.43) in men and 1.60 ( 95% CI, 1.08 to 2.37) in women. After additional adjustment for cholesterol, these associations attenuated or even disappeared. The odds ratios of having atherosclerosis at specific sites ( carotid arteries and aortic-iliac-femoral tract) followed a similar pattern.Conclusions - Although Lp-PLA2 has been found to be independently associated with cardiovascular events, the association with measures of subclinical extracoronary atherosclerosis found in this study strongly attenuated or even disappeared after adjustment for cholesterol.