Serological evidence of exposure to a coronavirus antigenically related to severe acute respiratory syndrome virus (SARS-CoV-1) in the Grey-headed flying fox (Pteropus poliocephalus)
Serological evidence of exposure to a coronavirus antigenically related to severe acute respiratory syndrome virus (SARS-CoV-1) in the Grey-headed flying fox (Pteropus poliocephalus)
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DOI：
10.1111/tbed.13908
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发表时间：
2020-11-26
影响因子：
4.3
通讯作者：
Prowse, Thomas A. A.
中科院分区：
文献类型：
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作者：
Boardman, Wayne S. J.;Baker, Michelle L.;Prowse, Thomas A. A.
许多传染性病原体可以通过高度移动的物种传播，如蝙蝠可以作为病毒的储存宿主，如亨尼帕病毒，狂犬病毒和冠状病毒。在这项研究中，我们调查了2015年9月至2018年2月在澳大利亚阿德莱德采样的灰头狐蝠（Pteropus poliocephalus）中严重急性呼吸综合征病毒（SARS-CoV-1）和中东呼吸综合征病毒（MERS-CoV）蛋白抗原的血清流行病学。共收集了301份血清样本，并使用多重Luminex结合试验进行评价，使用有限混合物建模确定中位荧光强度阈值。我们发现了对SARS-CoV-1或相关抗原反应的抗体的证据，血清阳性率为42.5%（CI：34.3%-51.2%），但对MERS-CoV抗原反应的证据不足。这项研究提供的证据表明，在阿德莱德采样的灰头狐蝠已经暴露于SARS样冠状病毒。
Many infectious pathogens can be transmitted by highly mobile species, like bats that can act as reservoir hosts for viruses such as henipaviruses, lyssaviruses and coronaviruses. In this study, we investigated the seroepidemiology of protein antigens to Severe acute respiratory syndrome virus (SARS-CoV-1) and Middle eastern respiratory syndrome virus (MERS-CoV) in Grey-headed flying foxes (Pteropus poliocephalus) in Adelaide, Australia sampled between September 2015 and February 2018. A total of 301 serum samples were collected and evaluated using a multiplex Luminex binding assay, and median fluorescence intensity thresholds were determined using finite-mixture modelling. We found evidence of antibodies reactive to SARS-CoV-1 or a related antigen with 42.5% (CI: 34.3%-51.2%) seroprevalence but insufficient evidence of reactivity to MERS-CoV antigen. This study provides evidence that the Grey-headed flying foxes sampled in Adelaide have been exposed to a SARS-like coronavirus.