Influence of Thyroid Hormones and Transforming Growth Factor-β1 on Cystatin C Concentrations
Influence of Thyroid Hormones and Transforming Growth Factor-β1 on Cystatin C Concentrations
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DOI：
10.1177/147323001003800418
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发表时间：
2010-07-01
影响因子：
1.6
通讯作者：
Murakami, M.
中科院分区：
文献类型：
--
作者：
Kotajima, N.;Yanagawa, Y.;Murakami, M.
据报道，血清胱抑素C浓度在甲状腺功能亢进状态下升高。测定甲状腺功能异常患者血清胱抑素C（CystatinC）和转化生长因子β 1（TGF-β 1）的浓度，并研究3，5，3 '-三碘甲状腺原氨酸（T-3）和TGF-β 1对人肝母细胞瘤（Hep G2）细胞产生CystatinC的影响。Graves病患者血清胱抑素C和TGF-β 1浓度显著高于对照组。甲状腺功能不全患者甲状腺激素与胱抑素C、甲状腺激素与TGF-β 1、TGF-β 1与胱抑素C均呈显著正相关。甲亢治疗后血清胱抑素C和TGF-β 1浓度降低。T-3和TGF-β 1可增加Hep G2细胞中CystatinC mRNA水平和CystatinC分泌。这些结果表明，血清胱抑素C浓度增加甲状腺功能亢进症患者。其机制可能涉及血清TGF-β 1水平的升高以及T-3和TGF-β 1对胱抑素C产生的刺激作用。
Serum cystatin C concentrations are reported to increase in the hyperthyroid state. Serum concentrations of cystatin C and transforming growth factor-beta 1 (TGF-beta 1) were measured in patients with thyroid dysfunction, and the effects of 3,5,3'-tri-iodothyronine (T-3) and TGF-beta 1 on cystatin C production in human hepatoblastoma (Hep G2) cells were studied. Serum concentrations of cystatin C and TGF-beta 1 were significantly higher in patients with Graves' disease compared with control subjects. Significantly positive correlations were observed between thyroid hormones and cystatin C, thyroid hormones and TGF-beta 1, and TGF-beta 1 and cystatin C in patients with thyroid dysfunction. Serum concentrations of cystatin C and TGF-beta 1 decreased after treatment for hyperthyroidism. Cystatin C mRNA levels and cystatin C secretion were increased by T-3 and TGF-beta 1 in cultured Hep G2 cells. These results suggest that serum cystatin C concentrations increase in patients with hyperthyroidism. The mechanisms for this may involve elevation of serum TGF-beta 1 levels and the stimulatory effects of T-3 and TGF-beta 1 on cystatin C production.