Regulation of neuronal input transformations by tunable dendritic inhibition
Regulation of neuronal input transformations by tunable dendritic inhibition
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DOI：
10.1038/nn.3024
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发表时间：
2012-03-01
影响因子：
25
通讯作者：
Losonczy, Attila
中科院分区：
文献类型：
--
作者：
Lovett-Barron, Matthew;Turi, Gergely F.;Losonczy, Attila
将突触输入转化为动作电位输出是神经元的基本功能。哺乳动物海马体主细胞的动作电位输出模式编码空间和非空间信息，但神经元将其突触输入转换为给定输出的细胞和电路机制尚不清楚。通过结合体外光激活和细胞类型特异性药物遗传学沉默，我们发现树突抑制是小鼠海马 CA1 锥体细胞输入输出转换的主要调节因子，并通过门控驱动突发尖峰的树突电发生来发挥作用。靶向树突的中间神经元本身受到靶向锥体细胞胞体的中间神经元的调节，为通过局部抑制网络中的相互作用调节锥体细胞输出提供了突触基质。这些结果为皮质回路的分工提供了证据，其中不同的计算功能是由局部抑制神经元的亚型实现的。
Transforming synaptic input into action potential output is a fundamental function of neurons. The pattern of action potential output from principal cells of the mammalian hippocampus encodes spatial and nonspatial information, but the cellular and circuit mechanisms by which neurons transform their synaptic input into a given output are unknown. Using a combination of optical activation and cell type-specific pharmacogenetic silencing in vitro, we found that dendritic inhibition is the primary regulator of input-output transformations in mouse hippocampal CA1 pyramidal cells, and acts by gating the dendritic electrogenesis driving burst spiking. Dendrite-targeting interneurons are themselves modulated by interneurons targeting pyramidal cell somata, providing a synaptic substrate for tuning pyramidal cell output through interactions in the local inhibitory network. These results provide evidence for a division of labor in cortical circuits, where distinct computational functions are implemented by subtypes of local inhibitory neurons.