Patient Specific Prostate Segmentation in 3-D Magnetic Resonance Images
Patient Specific Prostate Segmentation in 3-D Magnetic Resonance Images
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DOI：
10.1109/tmi.2012.2211377
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发表时间：
2012-10-01
影响因子：
10.6
通讯作者：
Fripp, Jurgen
中科院分区：
文献类型：
--
作者：
Chandra, Shekhar S.;Dowling, Jason A.;Fripp, Jurgen
前列腺及其周围组织的准确定位在前列腺癌的治疗中是必不可少的。本文提出了一种新的方法，完全自动分割前列腺，包括其精囊，在几分钟内的磁共振（MR）扫描采集没有直肠内线圈。这种MR图像在外部射束放射治疗中是重要的，其中使用直肠内线圈是非常不期望的。分割是使用可变形模型获得的，该模型是动态训练的，因此它是特定于患者扫描的。该病例特异性可变形模型由患者特异性初始化三角化表面和在其初始化期间训练的图像特征模型组成。图像特征模型用于通过将图像特征（经由归一化互相关）模板匹配到扫描的特征来使初始化的表面变形。所产生的变形通过完善的简单表面平滑算法在表面上进行正则化，然后通过优化的形状模型使其在解剖学上有效。分割50例患者的3T MR临床扫描时，平均和中位数Dice相似系数（DSC）分别为0.85和0.87。中位DSC结果等于评价者间DSC，平均绝对表面误差为1.85 mm。该方法在前列腺尖端和精囊附近表现良好。
Accurate localization of the prostate and its surrounding tissue is essential in the treatment of prostate cancer. This paper presents a novel approach to fully automatically segment the prostate, including its seminal vesicles, within a few minutes of a magnetic resonance (MR) scan acquired without an endorectal coil. Such MR images are important in external beam radiation therapy, where using an endorectal coil is highly undesirable. The segmentation is obtained using a deformable model that is trained on-the-fly so that it is specific to the patient's scan. This case specific deformable model consists of a patient specific initialized triangulated surface and image feature model that are trained during its initialization. The image feature model is used to deform the initialized surface by template matching image features (via normalized cross-correlation) to the features of the scan. The resulting deformations are regularized over the surface via well established simple surface smoothing algorithms, which is then made anatomically valid via an optimized shape model. Mean and median Dice's similarity coefficients (DSCs) of 0.85 and 0.87 were achieved when segmenting 3T MR clinical scans of 50 patients. The median DSC result was equal to the inter-rater DSC and had a mean absolute surface error of 1.85 mm. The approach is showed to perform well near the apex and seminal vesicles of the prostate.