Early onset of subclinical atherosclerosis in women with gestational diabetes mellitus
Early onset of subclinical atherosclerosis in women with gestational diabetes mellitus
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DOI：
10.1002/uog.2687
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发表时间：
2006-02-01
影响因子：
7.1
通讯作者：
Yanik, F
中科院分区：
文献类型：
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作者：
Tarim, E;Yigit, F;Yanik, F
目的颈总动脉内膜-中膜厚度（CIMT）是一种无创评估亚临床动脉粥样硬化的指标。本研究的目的是探讨妊娠期糖尿病（GDM）妇女的CIMT。方法选择30例GDM妇女和40例未患GDM妇女作为对照组。在每位妇女禁食至少8小时后的早晨抽取血样，测量空腹葡萄糖、胰岛素、同型半胱氨酸、总胆固醇、高密度脂蛋白（HDL）胆固醇、甘油三酯、低密度脂蛋白（LDL）胆固醇和极低密度脂蛋白（VLDL）胆固醇的水平，以及两组的CIMT。结果GDM组的平均甘油三酯（P = 0.016）和VLDL胆固醇（P = 0.011）水平显著高于正常组。在血浆总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和胰岛素水平方面，两组之间没有显著差异。GDM患者的平均同型半胱氨酸（P = 0.027）和空腹血糖（P = 0.019）水平显著高于对照组。GDM患者的CIMT明显高于未受影响的女性（0.582 +/- 0.066 mm vs 0.543 +/- 0.049 mm, P = 0.006）。CIMT与产妇年龄（r = 0.316, P = 0.008）、进行50 g口服糖负荷试验时体重指数（BMI） （r = 0.414, P = 0.001）、同型半胱氨酸水平（r = 0.332, P = 0.008）、进行口服糖耐量试验时空腹血糖（r = 0.265, P = 0.031）和1 h血糖值（r = 0.410, P = 0.001）呈正相关。GDM与CIMT呈正相关（r = 0.372, P = 0.001）。然而，逐步多元回归分析显示，GDM/no GDM （95% Cl +0.012 ~ +0.076, P = 0.008）和50 g试验时的BMI （95% CI + 0.001 ~ + 0.009, P = 0.011）是与CIMT相关的独立参数。结论GDM患者的CIMT较未患GDM患者增高。版权所有2006 ISUOG。约翰·威利父子有限公司出版。
Objective Common carotid artery intima-media thickness (CIMT) is a non-invasively assessed marker of subclinical atherosclerosis. Our aim in this study was to investigate CIMT in women with gestational diabetes mellitus (GDM).Methods Thirty women with GDM and 40 unaffected women (as a control group) were included in the study. Blood samples were drawn from each woman in the morning after they had fasted for at least 8 h, and levels of fasting glucose, insulin, homocysteine, total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and very low-density lipoprotein (VLDL) cholesterol were measured, along with the CIMT in the two groups.Results The mean triglyceride (P = 0.016) and VLDL cholesterol (P = 0.011) levels in the GDM group were significantly higher than those in the unaffected women. There were no significant differences between the groups with respect to plasma levels of total cholesterol, HDL cholesterol, LDL cholesterol and insulin. The mean homocysteine (P = 0.027) and fasting glucose (P = 0.019) levels in women with GDM were significantly higher than those in the control group. Patients with GDM bad significantly higher CIMT than did the unaffected women (0.582 +/- 0.066 mm vs. 0.543 +/- 0.049 mm, P = 0.006). CIMT correlated positively with maternal age (r = 0.316, P = 0.008), body mass index (BMI) at the time of a 50-g oral glucose load test (r = 0.414, P = 0.001) and homocysteine levels (r = 0.332, P = 0.008), and fasting glucose (r = 0.265, P = 0.031) and 1-h glucose value (r = 0.410, P = 0.001) at the time of the oral glucose tolerance test. There was a positive correlation between the presence of GDM and CIMT (r = 0.372, P = 0.001). However, stepwise multiple regression analysis showed that GDM/no GDM (95% Cl +0.012 to +0.076, P = 0.008) and BMI at the time of the 50-g test (95% CI + 0.001 to + 0.009, P = 0.011) were independent parameters related to CIMT.Conclusion Women with GDM have increased CIMT compared with unaffected women. Copyright (c) 2006 ISUOG. Published by John Wiley & Sons, Ltd.