Lipid imaging with cluster time-of-flight secondary ion mass spectrometry
Lipid imaging with cluster time-of-flight secondary ion mass spectrometry
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DOI：
10.1007/s00216-008-2367-3
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发表时间：
2009-01-01
影响因子：
4.3
通讯作者：
Laprevote, Olivier
中科院分区：
文献类型：
--
作者：
Brunelle, Alain;Laprevote, Olivier
这篇简短的文章概述了目前使用簇飞行时间二次离子质谱法（TOF-SIMS）的生物成像质谱技术的现状。最近，TOF-SIMS成像方法在灵敏度方面取得了惊人的进步，这使得许多生物学应用最近得到了成功的测试，例如，对患有营养不良的患者的人体肌肉中的脂质紊乱进行测绘，在细菌聚集在表面后对表面素进行定位，或对整个动物切片进行脂质测绘。
This brief article provides an overview of the current state of the art in biological imaging mass spectrometry using cluster time-of-flight secondary ion mass spectrometry (TOF-SIMS). Recent and spectacular improvements in terms of sensitivity of TOF-SIMS imaging methods have allowed many biological applications to recently be successfully tested, such as mapping of lipid disorders in human muscles of a patient suffering from dystrophy, localization of surfactins after the swarming of bacteria on a surface, or lipid mapping over whole-body animal sections.