Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat
Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat
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DOI：
10.1016/s0006-8993(96)01429-1
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发表时间：
1997-03-21
期刊：
影响因子：
2.9
通讯作者：
Noble, LJ
中科院分区：
文献类型：
--
作者：
Cobbs, CS;Fenoy, A;Noble, LJ
对中度创伤性脑损伤后的脑切片进行还原型烟酰胺腺嘌呤二核苷酸磷酸心肌黄酶（NADPHd）组织化学和一氧化氮合酶（NOS）免疫细胞化学。损伤后 24 小时，皮质挫伤周围的微血管中 NADPHd 反应性显着增加，内皮型一氧化氮合酶 (eNOS) 亚型诱导出现。这种改变的微血管状态可能导致屏障破坏和充血，这是创伤性脑损伤的特征。
Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd) histochemistry and nitric oxide synthase (NOS) immunocytochemistry were performed on sections of brain after moderate traumatic brain injury. There was a pronounced increase in NADPHd reactivity and an induction of the endothelial NOS (eNOS) isoform in microvessels surrounding the cortical contusion by 24 h post-injury. This altered microvascular state may contribute to barrier breakdown and hyperemia which characterize traumatic brain injury.