Thoughts on the future of reproductive and perinatal epidemiology.
Thoughts on the future of reproductive and perinatal epidemiology.
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对生殖和围产期流行病学未来的思考。
DOI：
10.1111/ppe.12017
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发表时间：
2013
影响因子：
2.8
通讯作者：
M. Klebanoff
中科院分区：
文献类型：
--
作者：
R. Ness;L. Bodnar;C. Holzman;R. Platt;D. Savitz;G. Shaw;M. Klebanoff
自儿科和围产期流行病学研究学会成立以来的25年里，与生育、怀孕、生长和发育有关的许多问题都发生了变化。几乎不存在的整个研究领域，如健康和疾病的发展起源，已经蓬勃发展。孤独症，曾经被认为是一个模糊的罕见，现在被认为是令人沮丧的普遍;肥胖从不罕见到达到流行病，甚至危机的比例。虽然流行病学调查人员，在自己的，并与临床和实验室研究人员合作，已经了解了很多关于生殖疾病的机制，大多数假定的生殖风险和保护因素的调查时，儿科和围产期流行病学研究协会成立仍在积极调查。在过去的25年里，很少有被最终证明或否定的因果关系，除了叶酸用于预防神经管和其他出生缺陷，我们的先进知识基本上没有转化为不良事件发生率的降低。一些将传递给下一代科学家的紧迫问题涉及营养、早产、先兆子痫、叶酸、环境危害和生物统计学的作用。
Much of relevance to fertility, pregnancy, growth and development has changed in the 25 years since the Society for Pediatric and Perinatal Epidemiologic Research was founded. Entire fields of study that hardly existed, such as the Developmental Origins of Health and Disease, have blossomed. Autism, once considered an obscure rarity, is now recognised to be distressingly common; and obesity went from being not rare to reach epidemic, even crisis proportions. Although epidemiological investigators, on their own and in collaboration with clinical and laboratory investigators, have learned much about the mechanisms underlying reproductive disorders, most putative reproductive risk and protective factors that were under investigation when the Society for Pediatric and Perinatal Epidemiologic Research was founded are still under active investigation. Over the past 25 years few have been conclusively proven or disproven to be causal and, with the exception of folate for the prevention of neural tube and perhaps other birth defects, our advanced knowledge has by and large not translated into reduced occurrence of adverse events. Some of the pressing questions that will pass on to the next generation of scientists relate to nutrition, preterm birth, preeclampsia, folate, environmental hazards and the role of biostatistics.
影响因子：
5
作者：
Kelly, R.;Holzman, C.;Chung, H.
通讯作者：
Chung, H.
影响因子：
7.7
作者：
Catov, Janet M.;Ness, Roberta B.;Olsen, Jorn
通讯作者：
Olsen, Jorn