Association of 14-3-3 ε gene haplotype with completed suicide in Japanese
Association of 14-3-3 ε gene haplotype with completed suicide in Japanese
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DOI：
10.1007/s10038-005-0241-0
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发表时间：
2005-04
影响因子：
3.5
通讯作者：
M. Yanagi;O. Shirakawa;N. Kitamura;K. Okamura;K. Sakurai;N. Nishiguchi;T. Hashimoto;H. Nushida;Y. Ueno;Daiji Kanbe;M. Kawamura;K. Araki;H. Nawa;K. Maeda
中科院分区：
文献类型：
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作者：
M. Yanagi;O. Shirakawa;N. Kitamura;K. Okamura;K. Sakurai;N. Nishiguchi;T. Hashimoto;H. Nushida;Y. Ueno;Daiji Kanbe;M. Kawamura;K. Araki;H. Nawa;K. Maeda
遗传因素被认为与自杀有关。尽管一些遗传因素，如5-羟色胺能转导，与自杀有关，但结果并不一致。有一种可能性是，各种信号异常与自杀的生物易感性有关。我们利用基因芯片在自杀受害者的大脑中进行了全基因组基因表达的研究；14-3-3ε与神经发生有关，是芯片分析中自杀受害者大脑中上调的基因之一。Western印迹分析证实了这一点。为了探讨14-3-3-ε参与自杀发病的可能性，我们研究了14-3-3ε基因与完全性自杀的相关性。我们使用了三个高频SNP(rs1532976、rs3752826和rs9393)，发现两个等位基因(rs1532976和rs3752826)与完全自杀(p<；0.05)显著相关。此外，自杀完成组和对照组之间的单倍型分布差异有统计学意义(p=0.0005)。这一发现提示14-3-3ε是一个潜在的自杀易感基因，提示神经发生的失调可能参与了自杀的发生。
Genetic factors have been suggested to be involved in suicide. Although some genetic factors, such as serotonergic transduction, have been associated with suicide, the results are inconsistent. There is a possibility that various signaling anomalies are involved in the biological vulnerability to suicide. We carried out a genome-wide gene-expression study in the brains of suicide victims using DNA microarrays; 14-3-3 ε, which is related to neurogenesis, was one of the genes upregulated in the brains of suicide victims in the microarray analysis. This was confirmed by Western blot analysis. To examine the possibility of the involvement of 14-3-3 ε in the pathogenesis of suicide, we investigated the association of the 14-3-3 ε gene and completed suicide. We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p< 0.05). Moreover, the distribution of haplotype revealed a more significant difference between completed suicide and controls (p= 0.0005). This finding suggests that 14-3-3 ε is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide.