Not all (cells) who wander are lost: Upstream migration as a pervasive mode of amoeboid cell motility.
Not all (cells) who wander are lost: Upstream migration as a pervasive mode of amoeboid cell motility.
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DOI：
10.3389/fcell.2023.1291201
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发表时间：
2023
影响因子：
5.5
通讯作者：
Guin, Subham
中科院分区：
文献类型：
--
作者：
Buffone Jr, Alexander;Hammer, Daniel A.;Kim, Sarah Hyun Ji;Anderson, Nicholas R.;Mochida, Ai;Lee, Dong-Hun;Guin, Subham
白细胞具有在特定化学物质表面逆流而上的能力。上游迁移首先在体外表征了由细胞内粘附分子-1（ICAM-1）组成的表面上的T细胞。当整合素受体αLβ2（也称为淋巴细胞功能相关抗原-1或LFA-1）与ICAM-1结合时，就会发生上游迁移。LFA-1/ICAM-1相互作用是普遍存在的，广泛存在于白细胞运输中。在细胞在内皮的顶表面上停止后，将采用上游迁移，并且可能赋予跨内皮迁移和组织监视两者的优势。现在已经表明，负责从血管运输到组织中的几种其他活动的阿米巴样细胞，如边缘带B细胞、造血干细胞和嗜中性粒细胞（当巨噬细胞-1抗原Mac-1被阻断时），也可以在ICAM-1表面上向上游迁移。这篇综述将总结什么是已知的上游迁移的基本机制，哪些细胞已经显示出这种现象，以及上游迁移在生理和组织稳态中的可能作用。
Leukocytes possess the ability to migrate upstream—against the direction of flow—on surfaces of specific chemistry. Upstream migration was first characterized in vitro for T-cells on surfaces comprised of intracellular adhesion molecule-1 (ICAM-1). Upstream migration occurs when the integrin receptor αLβ2 (also known as lymphocyte function-associated antigen-1, or LFA-1) binds to ICAM-1. LFA-1/ICAM-1 interactions are ubiquitous and are widely found in leukocyte trafficking. Upstream migration would be employed after cells come to arrest on the apical surface of the endothelium and might confer an advantage for both trans-endothelial migration and tissue surveillance. It has now been shown that several other motile amoeboid cells which have the responsibility of trafficking from blood vessels into tissues, such as Marginal zone B cells, hematopoietic stem cells, and neutrophils (when macrophage-1 antigen, Mac-1, is blocked), can also migrate upstream on ICAM-1 surfaces. This review will summarize what is known about the basic mechanisms of upstream migration, which cells have displayed this phenomenon, and the possible role of upstream migration in physiology and tissue homeostasis.
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影响因子：
2.9
作者：
Garner, Rikki M.;Skariah, Gemini;Theriot, Julie A.
通讯作者：
Theriot, Julie A.
影响因子：
3.4
作者：
Hornung, Alexander;Sbarrato, Thomas;Valignat, Marie-Pierre
通讯作者：
Valignat, Marie-Pierre
影响因子：
1.4
作者：
Carvalho, Jerusa Martins;Souza, Marlon Knabben de;Oliveira, José Salvador Rodrigues de
通讯作者：
Oliveira, José Salvador Rodrigues de
DOI：
10.1098/rspb.1988.0038
发表时间：
1988-06-22
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DEMBO, M;TORNEY, DC;HAMMER, D
通讯作者：
HAMMER, D
生化和机械的细胞外基质特性决定了乳腺上皮细胞运动和组装。
影响因子：
4.7
作者：
Shebanova, Olga;Hammer, Daniel A.
通讯作者：
Hammer, Daniel A.