Sono-photoacoustic imaging of gold nanoemulsions: Part II. Real time imaging.
Sono-photoacoustic imaging of gold nanoemulsions: Part II. Real time imaging.
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DOI：
10.1016/j.pacs.2015.01.001
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发表时间：
2015-03
期刊：
影响因子：
7.9
通讯作者：
O'Donnell, Matthew
中科院分区：
文献类型：
--
作者：
Arnal, Bastien;Wei, Chen-Wei;Perez, Camilo;Nguyen, Thu-Mai;Lombardo, Michael;Pelivanov, Ivan;Pozzo, Lilo D;O'Donnell, Matthew
使用外源性试剂的光声（PA）成像可能受到由于强背景信号而导致的特异性降低的限制。本文介绍了一种被称为声光声（SPA）的技术应用于全氟己烷纳米液滴涂有金纳米球。脉冲激光和超声（US）激发同时应用于造影剂，以诱导相变，最终产生瞬态微泡。在相变期间存在的US场与气泡的大的热膨胀相结合导致20-30 dB的信号增强。使用脉冲激光辐射在诊断曝光和传统的US阵列用于激发和成像的水溶液和phantomy与非常低浓度的这种剂进行了探测。该试剂的对比特异性用相干差分方案来证明，以抑制US和线性PA背景信号。SPA显示出巨大的潜力，分子成像与超灵敏检测的目标金涂层纳米乳液和空化辅助治疗诊断方法。
Photoacoustic (PA) imaging using exogenous agents can be limited by degraded specificity due to strong background signals. This paper introduces a technique called sono-photoacoustics (SPA) applied to perfluorohexane nanodroplets coated with gold nanospheres. Pulsed laser and ultrasound (US) excitations are applied simultaneously to the contrast agent to induce a phase-transition ultimately creating a transient microbubble. The US field present during the phase transition combined with the large thermal expansion of the bubble leads to 20–30 dB signal enhancement. Aqueous solutions and phantoms with very low concentrations of this agent were probed using pulsed laser radiation at diagnostic exposures and a conventional US array used both for excitation and imaging. Contrast specificity of the agent was demonstrated with a coherent differential scheme to suppress US and linear PA background signals. SPA shows great potential for molecular imaging with ultrasensitive detection of targeted gold coated nanoemulsions and cavitation-assisted theranostic approaches.