Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells.
Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells.
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DOI：
10.4252/wjsc.v6.i2.203
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发表时间：
2014-04
影响因子：
4.1
通讯作者：
T. Yazawa;Yoshitaka Imamichi;K. Miyamoto;A. Umezawa;T. Taniguchi
中科院分区：
文献类型：
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作者：
T. Yazawa;Yoshitaka Imamichi;K. Miyamoto;A. Umezawa;T. Taniguchi
激素替代治疗对肾上腺和性腺功能衰竭的患者是必要的。类固醇激素治疗也用于性激素缺乏的老年人。这些患者在其整个生命中接受具有相关风险的此类治疗。干细胞代表了组织再生的创新工具和解决这些问题的可能性。在各种干细胞类型中，间充质干细胞具有在体内和体外分化为类固醇生成细胞的潜力。特别地，它们可以通过在cAMP的帮助下表达核受体5A亚家族蛋白（类固醇生成因子-1和肝受体同系物-1）而有效地分化成类固醇生成细胞。这种方法将为未来的再生医学提供细胞来源，用于治疗由类固醇生成缺陷引起的疾病。它也可以代表一个有用的工具，用于研究类固醇生成及其相关疾病的分子机制。
Hormone replacement therapy is necessary for patients with adrenal and gonadal failure. Steroid hormone treatment is also employed in aging people for sex hormone deficiency. These patients undergo such therapies, which have associated risks, for their entire life. Stem cells represent an innovative tool for tissue regeneration and the possibility of solving these problems. Among various stem cell types, mesenchymal stem cells have the potential to differentiate into steroidogenic cells both in vivo and in vitro. In particular, they can effectively be differentiated into steroidogenic cells by expressing nuclear receptor 5A subfamily proteins (steroidogenic factor-1 and liver receptor homolog-1) with the aid of cAMP. This approach will provide a source of cells for future regenerative medicine for the treatment of diseases caused by steroidogenesis deficiencies. It can also represent a useful tool for studying the molecular mechanisms of steroidogenesis and its related diseases.