Obesity Augments Calcium-Induced Increases in Skeletal Calcium Retention in Adolescents
Obesity Augments Calcium-Induced Increases in Skeletal Calcium Retention in Adolescents
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DOI：
10.1210/jc.2010-2709
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发表时间：
2011-07-01
影响因子：
5.8
通讯作者：
Weaver, Connie M.
中科院分区：
文献类型：
--
作者：
Hill, Kathleen M.;Braun, Michelle M.;Weaver, Connie M.
背景：超重青少年体重骨矿含量低，骨折风险增加。目的：确定超重和肥胖是否影响青少年膳食钙摄入量和骨骼钙滞留之间的正相关关系。设计：对青少年钙平衡研究的汇集数据进行分析。背景：参与者每人在受控环境中接受为期3周的钙平衡研究。参与者：参与者包括280名10-16岁的白人、黑人和亚裔男孩(n=73)和女孩(n=207)。主要结果衡量标准：身体质量指数(BMI)、钙摄入量、结果：钙摄入量、BMI、性别、种族和年龄可解释钙滞留的27.9%的变异。在低钙摄入量时，BMI对骨钙保持没有影响，但在高钙摄入量时，BMI增加了骨钙保持。结论：与低BMI青少年相比，高BMI青少年的钙摄入量增加，钙滞留增加。还需要更多的研究来调查增加钙摄入量是否会降低青少年超重和肥胖导致的骨折风险增加。(临床内分泌代谢酶96：2171-2177,2011)
Context: Overweight adolescents have low bone mineral content for weight and are at increased risk for fractures.Objective: The aim was to determine whether overweight and obesity influence the positive relationship between dietary calcium intake and skeletal calcium retention in adolescents.Design: Analysis of pooled data from calcium balance studies in adolescents.Setting: Participants each underwent a 3-wk calcium balance study in a controlled environment.Participants: Participants included 280 White, Black, and Asian boys (n = 73) and girls (n = 207) ages 10-16 yr.Main Outcome Measure: The relationship among body mass index (BMI), calcium intake, and calcium retention was modeled using linear regression.Results: Calcium intake, BMI, sex, race, and age explained 27.9% of the variation in calcium retention. At low calcium intakes, there was no effect of BMI on skeletal calcium retention, but at higher calcium intakes, BMI increased skeletal calcium retention.Conclusions: Greater gains in calcium retention occur with increases in calcium intake in adolescents with higher BMI compared with those with lower BMI. Additional studies are needed to investigate whether increasing calcium intake reduces the increased risk of fracture associated with overweight and obesity in adolescents. (J Clin Endocrinol Metab 96: 2171-2177, 2011)