Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence.
Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence.
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DOI：
10.3389/fimmu.2021.714742
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发表时间：
2021
影响因子：
7.3
通讯作者：
Bartley JM
中科院分区：
文献类型：
--
作者：
Martin DE;Torrance BL;Haynes L;Bartley JM
众所周知，衰老与代谢失调有关。这在全身代谢方面以及在具有明显线粒体功能障碍的细胞水平上都可以看到。最近，免疫细胞中细胞代谢或免疫代谢的重要性已被强调为免疫细胞功能的主要调节剂。事实上，T细胞活化、分化和效应子功能部分取决于不同细胞类型和功能的代谢途径的改变，这些代谢途径有利于糖酵解或氧化磷酸化。虽然随着年龄的增长，免疫系统功能障碍得到了很好的描述，但仍然不太清楚的是控制免疫细胞代谢的整体网络如何受到年龄的影响。近年来，这一显著的差距已经被确定，并且已经开始研究免疫代谢可能受到实际年龄和年龄相关症状（如衰老细胞的全身积累）影响的各种方式。在这里，在这篇小型综述中，我们将研究免疫代谢，重点是T细胞，衰老和干预措施，如mTOR调节剂和senolytics。这篇评论还涵盖了一个及时的观点，如何免疫代谢可能是一个理想的目标，免疫调节与老化。
It is well known that aging is associated with dysregulated metabolism. This is seen both in terms of systemic metabolism, as well as at the cellular level with clear mitochondrial dysfunction. More recently, the importance of cellular metabolism in immune cells, or immunometabolism, has been highlighted as a major modifier of immune cell function. Indeed, T cell activation, differentiation, and effector function partly depend on alterations in metabolic pathways with different cell types and functionality favoring either glycolysis or oxidative phosphorylation. While immune system dysfunction with aging is well described, what remains less elucidated is how the integral networks that control immune cell metabolism are specifically affected by age. In recent years, this significant gap has been identified and work has begun to investigate the various ways immunometabolism could be impacted by both chronological age and age-associated symptoms, such as the systemic accumulation of senescent cells. Here, in this mini-review, we will examine immunometabolism with a focus on T cells, aging, and interventions, such as mTOR modulators and senolytics. This review also covers a timely perspective on how immunometabolism may be an ideal target for immunomodulation with aging.
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DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
DOI：
10.1016/j.bbrc.2019.03.199
发表时间：
2019-05-28
影响因子：
3.1
作者：
Chini, Claudia;Hogan, Kelly A.;Chini, Eduardo
通讯作者：
Chini, Eduardo
影响因子：
64.8
作者：
Araki, Koichi;Turner, Alexandra P.;Shaffer, Virginia Oliva;Gangappa, Shivaprakash;Keller, Susanne A.;Bachmann, Martin F.;Larsen, Christian P.;Ahmed, Rafi
通讯作者：
Ahmed, Rafi
影响因子：
29
作者：
Camacho-Pereira J;Tarragó MG;Chini CCS;Nin V;Escande C;Warner GM;Puranik AS;Schoon RA;Reid JM;Galina A;Chini EN
通讯作者：
Chini EN
影响因子：
20.8
作者：
Covarrubias AJ;Kale A;Perrone R;Lopez-Dominguez JA;Pisco AO;Kasler HG;Schmidt MS;Heckenbach I;Kwok R;Wiley CD;Wong HS;Gibbs E;Iyer SS;Basisty N;Wu Q;Kim IJ;Silva E;Vitangcol K;Shin KO;Lee YM;Riley R;Ben-Sahra I;Ott M;Schilling B;Scheibye-Knudsen M;Ishihara K;Quake SR;Newman J;Brenner C;Campisi J;Verdin E
通讯作者：
Verdin E