Differential effects of selective vagotomy and tropisetron in aminoprivic feeding
Differential effects of selective vagotomy and tropisetron in aminoprivic feeding
复制标题
DOI：
10.1152/ajpregu.2000.279.3.r997
复制
发表时间：
2000-09-01
影响因子：
2.8
通讯作者：
Gietzen, DW
中科院分区：
文献类型：
--
作者：
Dixon, KD;Williams, FE;Gietzen, DW
全膈下迷走神经切开术（TVAGX）和托司琼或昂丹司琼阻断血清素(3)受体均可减轻氨基酸不平衡饮食（Imb）厌食症。全迷走神经切断术在减少imb性厌食症方面不如托烷司琼有效，并且使托烷司琼的作用减弱。通过在迷走神经膈下水平使用电灼，我们分别或联合切断迷走神经腹侧和背侧干以及肝、胃腹侧、胃背侧、腹腔和腹腔副分支，以确定哪些迷走神经分支或相关结构可能参与这些反应。给大鼠喂食低蛋白食物。在实验第一天，在出现Imb前1小时腹腔注射托司司琼或生理盐水。包括腹侧分支，即TVAGX，腹侧迷走神经切开术（肝分支以上）和肝-胃迷走神经切开术（但不是单独的肝分支切开术）在内的切口在使用或不使用托司司琼时第1天的Imb摄入量最高（P< 0.05）。对托司司琼的反应无明显影响。在第2-8天，包括肝分支在内的迷走神经切除术组比假治疗组恢复得更快。由于肝分支和胃分支共同支配大部分十二指肠近端迷走神经支配，这一区域在初始反应中可能是重要的，而肝分支单独服务的结构显然在后来对Imb的适应中起作用。
Both total subdiaphragmatic vagotomy (TVAGX) and serotonin(3) receptor blockade with tropisetron or ondansetron attenuate amino acid-imbalanced diet (Imb) anorexia. Total vagotomy is less effective than tropisetron in reducing Imb-induced anorexia and also blunts the tropisetron effect. With the use of electrocautery at the subdiaphragmatic level of the vagus, we severed the ventral and dorsal trunks as well as the hepatic, ventral gastric, dorsal gastric, celiac, and accessory celiac branches separately or in combination to determine which vagal branches or associated structures may be involved in these responses. Rats were prefed a low-protein diet. On the first experimental day, tropisetron or saline was given intraperitoneally 1 h before presentation of Imb. Cuts including the ventral branch, i.e., TVAGX, ventral vagotomy (above the hepatic branch), and hepatic 1 gastric vagotomies (but not hepatic branch cuts alone) caused the highest (P< 0.05) Imb intake on day 1 with or without tropisetron. The responses to tropisetron were not affected significantly. On days 2-8, groups having vagotomies that included the hepatic branch recovered faster than sham-treated animals. Because the hepatic and gastric branches together account for most of the vagal innervation to the proximal duodenum, this area may be important in the initial responses, whereas structures served by the hepatic branch alone apparently act in the later adaptation to Imb.