The mouse gene expression database: New features and how to use them effectively.
The mouse gene expression database: New features and how to use them effectively.
复制标题
DOI：
10.1002/dvg.22864
复制
发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Ringwald M
中科院分区：
文献类型：
--
作者：
Finger JH;Smith CM;Hayamizu TF;McCright IJ;Xu J;Eppig JT;Kadin JA;Richardson JE;Ringwald M
基因表达数据库（GXD）是一个广泛和免费提供的小鼠发育表达数据的社区资源。GXD通过电子数据提交以及与大型项目的合作，从文献中整理和整合表达数据。作为小鼠基因组信息学（MGI）资源的一个组成部分，GXD将表达数据与遗传，功能，表型和疾病相关数据相结合，并为研究界提供工具，以在更大的背景下搜索和分析表达数据。最近的增强功能包括：交互式浏览器，用于导航小鼠发育解剖结构并查找特定解剖结构的表达数据;搜索位于特定基因组区域的基因的表达数据的能力，支持疾病候选基因的识别;显示符合指定搜索标准的所有表达图像的摘要;交互式矩阵视图，提供时空表达模式的概览（组织×阶段矩阵），并能够比较基因之间的表达模式（组织×基因矩阵）;数据缩放和过滤实用程序，以迭代方式优化汇总显示和数据集;以及基于基因的与来自其他模式生物的表达数据的链接，如鸡、非洲爪蟾和斑马鱼，促进与发育研究高度相关的物种的比较表达分析。
The Gene Expression Database (GXD) is an extensive and freely available community resource of mouse developmental expression data. GXD curates and integrates expression data from the literature, via electronic data submissions, and by collaborations with large-scale projects. As an integral component of the Mouse Genome Informatics (MGI) Resource, GXD combines expression data with genetic, functional, phenotypic and disease-related data, and provides tools for the research community to search for and analyze expression data in this larger context. Recent enhancements include: an interactive browser to navigate the mouse developmental anatomy and find expression data for specific anatomical structures; the capability to search for expression data of genes located in specific genomic regions, supporting the identification of disease candidate genes; a summary displaying all the expression images that meet specified search criteria; interactive matrix views that provide overviews of spatio-temporal expression patterns (Tissue × Stage Matrix) and enable the comparison of expression patterns between genes (Tissue × Gene Matrix); data zoom and filter utilities to iteratively refine summary displays and data sets; and gene-based links to expression data from other model organisms, such as chicken, Xenopus and zebrafish, fostering comparative expression analysis for species that are highly relevant for developmental research.