GAB2--a scaffolding protein in cancer.
GAB2--a scaffolding protein in cancer.
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DOI：
10.1158/1541-7786.mcr-12-0352
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Celebi JT
中科院分区：
文献类型：
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作者：
Adams SJ;Aydin IT;Celebi JT
衔接蛋白或支架蛋白介导蛋白质-蛋白质相互作用，从而驱动蛋白质复合物的形成。GAB 2支架蛋白是连接包括受体酪氨酸激酶在内的质膜受体信号传导与下游效应物如SHP 2、PI 3 K的p85亚基、PLCγ、CRK、SHC和SHIP的中间分子。虽然在信号转导中有很好的描述，但它在癌症中的作用最近才出现，特别是在白血病、乳腺癌和卵巢癌以及黑色素瘤中。GAB 2在肿瘤的两个主要信号转导途径PI 3 K-AKT和ERK信号转导途径中是必需的，并因此调节许多关键的细胞过程。本文综述了GAB 2的结构和功能，其调节蛋白，在癌症中的新作用，以及作为治疗靶点的潜力。
Adaptor or scaffolding proteins mediate protein-protein interactions that drive the formation of protein complexes. GAB2 scaffolding protein is an intermediary molecule that links plasma membrane receptor signaling including receptor tyrosine kinases with the downstream effectors such as SHP2, p85 subunit of PI3K, PLCγ, CRK, SHC and SHIP. Although well described in signal transduction, its role in cancer has recently been emerging especially in leukemia, breast and ovarian cancer, and melanoma. GAB2 is essential for two major signal transduction pathways in cancer, thePI3K-AKT and ERK signaling pathways, and thus regulates a number of key cellular processes. This review focuses on structure and function of GAB2, its regulatory proteins, emerging role in cancer, and potential as a therapeutic target.